The serum was analyzed for chlordane
analytes and other pesticides, and the results were compared among groups to determine if the consumption advisories reflected the level of chlordane
analytes in their blood.
In this analysis, we estimated a significant positive association between metastatic prostate cancer and prediagnostic serum concentrations of the chlordane
Such hormonally active chemicals include persistent organic pollutants (POPs) such as hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs), and chlordanes
. These contaminants, which chemically resemble estrogen, the primary female sex hormone, break down slowly in the environment and accumulate in fatty tissues of people and animals.
Deadly substances like DDT, chlordane
, PCBs and dioxin live for decades in a river's aquatic food chain.
Environmental Protection Agency (EPA) was founded in 1970 and soon afterward began regulating pesticides, such as banning all uses of chlordane
* The Stockholm Convention contains a list of nine chemical substances manufactured intentionally (aldrin, chlordane
, dieldrin, endrin, hexachlorobenzene (HCB), heptachlor, mirex, toxaphene and PCBs) whose production and use are banned except in the case of general or specific derogations.
Like many organic molecules, each chlordane
compound comes in two mirrorimage variants called enantiomers, which may break down at different rates in the environment.
Positive associations between exposure to chlordane
isomers and testicular germ cell tumors have been reported.
- Substances covered by both Conventions: aldrin, chlordane
, DDT, dieldrin, dioxins, endrin, furans, heptachlor, hexachlorobenzene (HCB), mirex, polychlorinated biphenyls (PCBs), toxaphene (also called camphechlor),
The Stockholm Convention lists nine intentionally-produced chemicals (aldrin, chlordane
, dieldrin, endrin, hexachlorobenzene or HCB, heptachlor, mirex, toxaphene and PCBs) which are subject to a ban on production and use except where there are generic or specific exemptions.
They are dioxins and related furans; polychlorinated biphenyls; and the pesticides aldrin, chlordane
, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, mirex, and toxaphene.
Given positive associations between chlordane
isomers and testicular germ cell tumors, it is reasonable to assume that chlordanes
might also be associated with other testicular dysgenesis syndrome disorders, namely cryptorchidism and hypospadias.