Robaszkiewicz and coworkers  studied the effects of chlorohydrin PCs on human erythrocytes.
It could also be shown that induced acute pancreatitis results in a substantial release not only of FFAs but also of the chlorohydrins of both oleic and linoleic acid from adipose tissue while accompanying plasma investigations evidenced only the chlorohydrin of oleic acid.
The first hint to the involvement of chlorinated lipid species in atherosclerosis was obtained in 1996 : Hazen and coworkers detected different chlorinated lipids upon the exposition of human LDL to the complete MPO system at acidic conditions with the focus on cholesterol: beside dichlorinated cholesterol, cholesterol a-chlorohydrin (6[beta]-chlorocholestane- (3[beta],5[alpha])-diol), cholesterol [beta]-chlorohydrin (5[alpha]-chlorocholestane-(3[beta], 6[beta])-diol), and a structurally related cholesterol chlorohydrin could be detected and characterized by MS.
Then, the three hydrolysates were isolated by preparative HPLC to afford two known compounds (i.e., deepoxydihydroxyenhydrin (2) and enhydrin chlorohydrin
HOCl reaction with cholesterol causes chlorohydrins
that could disrupt cell membranes, leading to cell lysis and death.
* Three chemicals -- propylene chlorohydrin
, phosgene and epichlorohydrin -- account for the vast majority of chlorine use for chemical intermediates (chemicals used to make other products).
chlorohydrin rubber (CHR) can readily form hydrogen bonds with water, and it possesses specific hydrophilicity.
Chlorohydrin rubber, the epichlorohydrin homopolymer, industrial product, with Mooney viscosity M[L.sub.1+4] (100[degrees]C) 60 ~ 70, was produced in the Cangzhou Synthetic Rubber Factory, Hebei Province, China.
Germination was not enhanced by subjecting seeds to ethylene chlorohydrin
vapors and solutions or using salt solutions of 0.1 to 0.8% KN[O.sub.3] as moistening agents (Ahring and Frank, 1968).
Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin
) (CAS No.
The epoxidation reaction of a polyol with epichlorohydrin is very well known (1, 2), and it occurs in two steps; 1, Formation of an intermediate chlorohydrin and 2 dehydrohalogenation to form the glycidyl ether
The chemical structures of an epoxy resin based on trimethylolpropane were examined and it was determined that the formation of epoxy resins was controlled by a previous step, "chlorohydrin formation," and no trifunctional resins were detected (6).