The data on the management of metformin-associated lactic acidosis, chlorpropamide
, methotrexate, and phenobarbital is even more limited.
Schaaf, "Comparison of clofibrate and chlorpropamide
in vasopressin-responsive diabetes insipidus," Metabolism: Clinical and Experimental, vol.
Effect of moderate dosage of chlorpropamide
in pregnancy on fetal outcome.
Rarely, neutropenia may occur as a result of idiosyncratic supression of myeloid production with antibiotics, anti-diabetics, antihistaminics and antihypertensive drugs, destruction of neutrophils related with differences in drug metabolism (phenothiazine, thiouracil) and leukocyte destruction due to antibodies developing against the leukocyte-drug complex (phenylbutasone, chlorpropamide
) (3, 4, 7, 8).
Phenacetin, paracetamol, metacetamol, oleanolic acid, tolbutamide, chlorpropamide
, furafylline, dextromethorphan, 6[beta]-hydroxytestosterone, glucose 6phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and tris (hydroxymethyl) aminomethane hydrochloride (Tris-HCl) were purchased from Sigma Chemical Co.
apocynaceae (Madagascar periwinkle) and chlorpropamide
(diabinese) on alloxan-induced diabetic rats," Biokemistri, vol.
Pharmaceuticals include a class of oral medications used to stimulate the beta cells to release more insulin, such as sulfonylureas, meglitin ides, and chlorpropamide
. In addition, there are medications that block the breakdown of starches; these include alpha-glucosides inhibitors and DPP-4 inhibitors.
Bauer, "Medication compliance in non-insulin-dependent diabetes: a randomized comparison of chlorpropamide
and insulin," Diabetes Care, vol.
The first generation sulfonylureas (tolbutamide, tolazamide and chlorpropamide
) are rarely used now.
All other contraindications for disulfiram therapy such as (i) subjects receiving or have recently received alcohol, or alcoholcontaining preparations such as cough syrups, elixirs (ii) hypersensitivity to disulfiram or other thiuram derivatives used in the manufacture of items such as pesticides or vulcanized rubber, (iii) concomitant treatment with cefaperazone, chlorpropamide
, metronidazole, paraldehyde, nitrofurantoin, griseofulvin, tolbutamide, desipramine, amitriptyline, isoniazid, phenytoin, phenlybutazone, and sulphonylurea class of hypoglycemic agents and (iv) allergy to disulfiram
The administration of the insulin secretagogue drug chlorpropamide
in fish leads to the hypoglycaemic effects (Al-Salahy, 2003) and insulin injections into fish also induced hypoglycaemia (Ottolenghi et al., 1982; Carneiro and Amaral, 1983; Al-Salahy et al., 1994).
In contrast, patients receiving chlorpropamide
or glibenclamide gained an average of 3 to 4 kg, while insulin treated patients gained approximately 6 kg.