chlorzoxazone


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chlorzoxazone

[klȯr′zäks·ə‚zōn]
(pharmacology)
C7H4ClNO2 Crystals with a melting point of 191-191.5°C; soluble in aqueous solutions of alkali hydroxides and in ammonia; used as a skeletal muscle relaxant.
References in periodicals archive ?
The difference between the thiocolchicoside and chlorzoxazone group before and after administration of the respective drugs were compared using unpaired t-test.
Girre et al., "Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects," Pharmacogenetics, vol.
In the 15th day, the mixed probe drugs containing caffeine, chlorzoxazone, tolbutamide, and midazolam were administered intravenously (by caudal vein) at a dosage of 2.5,5,5, and 5 mg/kg.
The retention times for IS, phenacetin, tolbutamide, chlorzoxazone, and testosterone were 5.28, 8.50, 6.70, 11.03, and 17.66 min, respectively (Figure 1(b)).
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms.
The list of potentially inappropriate drugs included propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cyclobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolam, chlordiazepoxide, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
The list of potentially inappropriate drugs included: propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cyclobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolain, chlordiazepoxide, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
The list included propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cydobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolam, chlordiazepoxide, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
These include tricyclic antidepressants, neuroleptics, beta-blockers and other antiarrhythmics (CYP2D6); paracetamol, chlorzoxazone and ethanol (CYP2E1) and hydrazines, arylamines, pyrazolones, caffeine and nitrazepam (NAT2) among others.
Four weeks after being discharged, the patient no longer required muscle relaxants (Chlorzoxazone) and was able to perform most of her activities of daily living without pain.
The muscle relaxant chlorzoxazone (Algisin, Paraflex, Parafon Forte), the antibiotic rifampin (Rifadin, Rofact), antipsychotics, and some antiparasitic medications may cause spectacular colorations in urinary discharge.