Cholangitis


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cholangitis

[‚kō· lən′jīd·as]
(medicine)
Inflammation of the bile ducts.

Cholangitis

 

(also angiocholitis), inflammation of the bile ducts owing to infection; the infection spreads into the bile ducts, in most cases, from the gallbladder, intestine, or blood vessels; less commonly, its path is through the lymphatic system. Cholestasis, or stoppage of the flow of bile, contributes to the development of the disease. Cholangitis is caused mainly by chronic inflammation of the gallbladder and the subsequent spread of the infection to the biliary tract. Cholangitis may be acute or chronic; depending on the types of changes in the ducts, it may be catarrhal or purulent. Symptoms include dyspepsia, elevated body temperature, jaundice, and changes in the composition of the blood.

References in periodicals archive ?
(1) The former include primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), graft-versus-host-disease (GVHD), and drug-induced liver injury (DILI).
A 36-year-old man was admitted to hospital in November 2012 with recurrent cholangitis. At the age of 5 years he had had an oesphageal variceal bleed secondary to an extrahepatic portal vein thrombosis following umbilical vein sepsis caused by a venous catheter used during a neonatal illness.
Estimates suggest that 25% to 50% of cases could be autosomal recessive, the balance being sporadic, although no clear genetic basis for the disease has been identified.[sup.5] Caroli's disease is characterized by segmental dilatation of the intrahepatic bile ducts without hepatic fibrosis as compared to Caroli's syndrome, which is defined as ectasia of the intrahepatic bile ducts with hepatic fibrosis.[sup.6,7] Clinically, patients with Caroli's disease often develop portal hypertension, fat-soluble vitamin deficiency (vitamin K in particular) and are at increased risk for intrahepatic stones and severe septic cholangitis.
Data Source: A review of data from 54 patients seen at the Mayo Clinic, Rochester, Minn., for primary sclerosing cholangitis and inflammatory bowel disease and later diagnosed with colonic neoplasms.
Over the next few months, the man was admitted for repeated cholangitis episodes.
Adults however present mainly with pain (2,3) and complications of longstanding cysts such as recurrent cholangitis, pancreatitis and malignancies.
Only severe or worsening cholangitis requires urgent intervention.
ChemomAb is a clinical stage biopharmaceutical company, specializing in the development of proprietary monoclonal antibodies, directed towards novel targets, for the treatment of fibrotic-inflammatory disorders including NASH, as well as the orphan indications Primary Sclerosing Cholangitis and Systemic Sclerosis.
Announced FDA acceptance of an IND to initiate a Phase 2 clinical study of seladelpar in primary sclerosing cholangitis (PSC).
Microbiome company BiomX Ltd said on Monday that it has entered into an agreement to license a new set of bacterial targets for the development and commercialisation of phage therapies for the treatment of orphan liver disease Primary Sclerosing Cholangitis (PSC) from JSR Corporation, Japan.
Vestra said that Arquilita had been in the hospital since March 29 after he was diagnosed with anemia, cholangitis or inflammation of the bile duct and viral Hepatitis B.