To systematically link the observed arousal changes to the cholinergic
system, the team took advantage of an earlier discovery by Hensch: mice lacking the LYNX1 protein exhibit enhanced cholinergic
Not only does this cholinergic
system act as a master switch, but mounting evidence suggests it also enables the brain to identify which sensory input is the most salient - i.e.
This effect has been suggested to imply an anticholinergic as well as cholinergic
activity due to their efficacy in increasing the release of acetylcholine.
The fluorescence of PGP 9.5 [Figure 2]b and [Figure 3]a1,[Figure 3]a2,[Figure 3]a3, TH [Figure 2]d and [Figure 3]b1,[Figure 3]b2,[Figure 3]b3, and VIP [Figure 2]f and [Figure 3]c1,[Figure 3]c2,[Figure 3]c3 appeared on nerve fibers surrounding the eccrine sweat glands, indicating that human eccrine sweat glands were innervated by both adrenergic and cholinergic
 Loss of cholinergic
, glutaminergic and serotonergic neurons due to oxidative stress are also implicated in dementia.
The present study used an active oddball paradigm to demonstrate that P300-like responses and related EROS could be generated in rats under baseline conditions and to confirm that this P300-like response of attentive and memory processing is sensitive to modulation of cholinergic
Considering the relationship between the cholinergic
nerve system and AD, the development of a VAChT imaging agent is important.
Generation of functional dopaminergic neurons from hiPSCs described in various protocols is relatively robust and reproducible, while cholinergic
neurons production still requires optimization and increase efficiency.
Prolongation of acetylcholine (ACh) release into the neuronal synaptic cleft has been targeted as a means of increasing cholinergic
functions in AD, which can be achieved by blocking enzymatic hydrolysis of acetylcholine by AChE .
The pharmacological mechanism of GBE partly involves the modulation of inflammatory mediators and the cholinergic
Proposed by Janowsky et al (10) in 1972, the cholinergic-adrenergic balance hypothesis of affective disorders suggests that depression represents an excess of central cholinergic
tone over adrenergic tone, and that mania represents the opposite imbalance.
Control of thermoregulation in the central nervous system occurs mainly in the hypothalamus, and previous studies have shown that cholinergic
pathways are involved in this central control (34).