acetylcholine receptor

(redirected from cholinergic receptor)
Also found in: Dictionary, Thesaurus, Medical, Legal.
Related to cholinergic receptor: adrenergic receptor, Nicotinic receptor

acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
References in periodicals archive ?
The immunogenic theory, which has been postulated to explain the pathogenic process leading to Chagas' cardiomyopathy, also involves the cholinergic system with reports of the existence of autoimmune antibodies against M2 muscarinic (15) and nicotinic cholinergic receptors (16).
For example, depressed patients have been found to have hypersensitive central cholinergic receptors.
Varenicline-Nicotinic Receptor Partial Agonist: Varenicline is a nicotinic receptor partial agonist acting mainly on the [alpha][beta][beta]2 subtype of the nicotinic cholinergic receptor.
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.
Tobacco and alcohol use may be related at least partially because both nicotine and alcohol affect brain nicotinic cholinergic receptors (Collins 1990; Little 2000).
The cerebellar changes in the later stages of development, however, could not have been the result of cholinesterase inhibition because the cerebellum is not innervated with cholinergic receptors like the forebrain is (Crumpton et al.
Keywords: Catharanthus roseus roots Catharanthine Ajmalicine Serpentine Acetylcholinesterase Cholinergic Receptors
That receptor, which contains the nicotinic a-7 cholinergic receptor subunit, is necessary to inhibit the release of TNF and other pro-inflammatory cytokines.
Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one mediated through stimulation of nicotinic cholinergic receptors and the other targeting intracellular signaling.
Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with [sup.
It is also an intermediate of the phosphatidylinositol cycle, a second-messenger neuronal signaling system used by noradrenergic, serotonergic, and cholinergic receptors.
The drug's binding profile is marked by high affinity and selectivity for 5-HT2A receptors, a feature that appears to be effective for treating PD psychosis, with no appreciable affinity for adrenergic, dopaminergic, histaminergic, or cholinergic receptors.