and Their Consideration in the Radiographic Differential of Extra-Axial Lesions of the Central Nervous.
DISCUSSION: Sinuous nature of the notochord remnants at the base of the skull explains the various sites of predilection of cranial chordomas
are found along the axial skeleton and a relatively evenly distributed among three locations, sacro-coccygeal 30-50%,spheno-occipital 30-35% and vertebral body 15-30%.
Presneau et al., "Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
," Journal of Pathology, vol.
The hospital revealed that the boy, identified only as Tristan, was facing certain death from a chordoma
, a rare, malignant brain tumour, which had wrapped around the 4-year-old's brain stem, making it impossible to use normal surgical techniques.
Abstract: Cervical chordomas
are rare, slow-growing, but locally aggressive tumors.
Visualization of tumors such as ependymomas, astrocytomas, Schwannomas and chordomas
gives insight into the disease process.
The Massachusetts group has also treated 67 patients with chordomas
or chondrosarcomas of the base of the skull or cervical spine--a rather rare tumor, Austin-Seymour says.
are malignant tumors originating from embryonic notochord remnants in the craniospinal axis, mostly the sacrococcygeal (50 percent) and the spheno-occipital regions (35 percent), though 15 percent can occur in the true vertebrae.
are rare malignant neoplasms that arise from persistent notochord elements.[sup] Approximately, half of all chordomas
arise in the sacrococcygeal area, 30% in the base of the skull, and 20% in the mobile spine.
"Given that extra-axial chordomas
are rare and our case of extra-axial dedifferentiated chordoma
is even rarer, brachyury is extremely useful in confirming the diagnosis," they said, adding that brachyury nuclear expression has been observed in most axial and skull-based chordomas
, ranging between 89.7% and 100%, including dedifferentiated and metastatic ones.
The second edition of this guide to spine radiosurgery has six new chapters, including histopathological examination of spinal lesions, minimally invasive surgeries, and treatment of spinal chordomas
. New discussions of treatments for metastatic spinal disease and spinal chord compression are also included.