chorionic villus sampling


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chorionic villus sampling

(CVS) or

chorionic villus biopsy

(CVB) (kōr'ē-ŏn`ĭk, kôr'–), diagnostic procedure in which a sample of chorionic villi from the developing placenta is removed from the uterus of a pregnant woman (see pregnancypregnancy,
period of time between fertilization of the ovum (conception) and birth, during which mammals carry their developing young in the uterus (see embryo). The average duration of pregnancy in humans is about 280 days, equal to 9 calendar months.
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) using a fine needle inserted through the abdomen or a thin plastic catheter inserted into the vagina and through the cervix. Chorionic villi are fingerlike projections of a membrane (the chorion) that surrounds the fetus. The villi develop from the fertilized ovumovum
, in biology, specialized plant or animal sex cell, also called the egg, or egg cell. It is the female sex cell, or female gamete; the male gamete is the sperm. The study of the ovum is included in the science of embryology.
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, or egg, and have a genetic composition similar to that of the fetus. Cells in the sample are grown in the laboratory and studied to detect the presence in the fetus of such genetic birth defectsbirth defects,
abnormalities in physical or mental structure or function that are present at birth. They range from minor to seriously deforming or life-threatening. A major defect of some type occurs in approximately 3% of all births.
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 as Tay-Sachs diseaseTay-Sachs disease
, rare hereditary disease caused by a genetic mutation that leaves the body unable to produce an enzyme necessary for fat metabolism in nerve cells, producing central nervous system degeneration.
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 and Down syndromeDown syndrome,
congenital disorder characterized by mild to severe mental retardation, slow physical development, and characteristic physical features. Down syndrome affects about 1 in every 730 live births and occurs in all populations equally.
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. The sex of the child can also be ascertained. Although CVS tests for the same range of abnormalities as amniocentesisamniocentesis
, diagnostic procedure in which a sample of the amniotic fluid surrounding a fetus is removed from the uterus by means of a fine needle inserted through the abdomen of the pregnant woman (see pregnancy).
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, it is usually performed some weeks earlier (between the 8th and 12th weeks of pregnancy), and the results are available in a few days. It is recommended if the parents are carriers of certain genetic diseases, if there is a family history of genetic disorders, or if the woman is over age 35 (later pregnancies carrying with them a higher risk of chromosomal abnormality).

chorionic villus sampling

[¦kör·ē‚an·ik ′vil·əs ‚sam·pliŋ]
(medicine)
A technique in which samples of chorionic villi are taken from the placenta for the purpose of genetic testing; usually performed at the end of the second month of pregnancy.
References in periodicals archive ?
Outcome of 1,355 consecutive transabdominal chorionic villus samplings in 1,351 patients].
Checking their findings against chorionic villus sampling, the researchers identified the mutations in the circulating fetal DNA with almost 100 percent accuracy.
CHORIONIC VILLUS SAMPLING (CVS): This test is done after the 11th week of pregnancy.
Chorionic Villus Sampling (CVS): Optional test performed in the ninth to 11th week.
Now they can study the fetus as early as the ninth to 12th weeks of pregnancy with the chorionic villus sampling test.
Caroline McGuirk, project coordinator of the Chorionic Villus Sampling Birth Defects Registry at Massachusetts General Hospital in Boston, said, "Many women have CVS, and many of their children do not have birth defects.
If there is an increased risk for chromosomal or genetic abnormalities, chorionic villus sampling (CVS) may be performed at ten to 12 weeks of pregnancy.
Now, amniocentesis and chorionic villus sampling can tell expectant parents whether their child will be born with sickle-cell anemia, thalassemia, or certain other genetic diseases.
Based on our in-depth study and analysis of the industry, we have identified preliminary testing, first trimester screening, second trimester screening, chorionic villus sampling testing and amniocentesis testing as the major areas of testing in the US prenatal testing market.