Until recently, it was believed that NB originates from the cells of the developing sympathetic nervous system, probably from sympathoadrenal progenitor cells that normally differentiate into sympathetic ganglion cells and adrenal chromaffin cells
(catecholamine-secreting adrenal cortex cells) .
Pheochromocytomas and extra-adrenal paragangliomas (PGLs) are catecholamine-secreting tumors that arise from neural-crest derived chromaffin cells
(14) There are also interesting reports of adrenal medullary transplant or purified adrenal chromaffin cells
' transplant for the managemant of chronic pain, (15) and pain of central origin after spinal cord hemisection, (16) and in cases of intractable cancer pain.
Cellular 'neoteny': a possible developmental basis for chromaffin cell
Pheochromocytoma (PHEO; MIM #171300) is a rare neuroendocrine tumor of chromaffin cells
originating in the adrenal medulla, whereas paragangliomas (PGLs; MIM #168000) are even rarer tumors arising in the paraganglia along the parasympathetic and sympathetic chains .
Pheochromocytomas and paragangliomas (PPGLs)  are neuroendocrine tumors arising from adrenal and extraadrenal chromaffin cells
, respectively (1).
Lumbar intrathecal transplant is easiest in humans and was used in all the earlier adrenal chromaffin cell
therapy for chronic pain in humans [82-83].
Pheochromocytoma is a catecholamine-producing tumor that originates from the adrenal medulla or extra-adrenal chromaffin cells
. The main clinical manifestation of pheochromocytoma is paroxysmal or persistent hypertension, accompanied by arrhythmias, such as sinus tachycardia, paroxysmal supra VT, atrial fibrillation, or ventricular premature contractions.
The interference affects measurements of methoxytyramine, the O-methylated metabolite of dopamine, important for diagnosis of chromaffin cell
tumors and identification of metastatic disease (2, 3).
Paraganglioma is a rare chromaffin cell
tumour from extraadrenal symphatetic tissue and is mostly located in the abdomen.
Ultrastructural organization of bovine chromaffin cell
cortex--analysis by cryofixation and morphometry of aspects pertinent to exocytosis.
[Ca.sup.2+]/Calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell
functions, Journal of Neurochemistry, 2517-2522.