chromomycin

chromomycin

[¦krō·mō′mī·sən]
(microbiology)
Any of five components of an antibiotic complex produced by a strain of Streptomyces griseus; components are designated A1 to A5, of which A3(C51H72O32) is biologically active.
References in periodicals archive ?
Alternatively, after staining with DAPI, further staining was performed with chromomycin A3 (CMA) at a concentration of 0.
In human, percentage of sperm stained positively with Chromomycin A3, an indication of deprotamination, had a positively correlation with macrocephaly sperm [14].
Fluorescent chromosome banding to reveal the type, amount, size and distribution of Het was performed according to the triple staining technique (CDD) of Schweizer and Ambros (1994), using the fluorochromes chromomycin A3 (CMA), distamycin A (DA) and 4-6-diamidino-2-phenylindole (DAPI).
9 [micro]M) were the most potent compounds in this group; aclarubicin hydrochloride, plicamycin, and the structurally related chromomycin A3 were also active, whereas adriamycin hydrochloride was inactive.
The GC and AT rich regions were detected using the fluorochromes Chromomycin [A.
The DNA-binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells," British Journal of Haematology, vol.
Several tests such as TdT (terminal deoxyribonucleotidyl transferase)-mediated dUTP nick-end labeling (TUNEL) assay, aniline blue straining, chromomycin A3 and acridine orange (AO) staining have been described to determine the extent of DNA damage.
Notorious examples include 4'-6-diamidino-2-phenylindole (DAPI), which highlights AT-rich regions, and chromomycin A3 ([CMA.
Chromomycin A3 (CMA3) is a guanine-cytosine-specific fluorochrome and indicative of poor chromatin packaged in human sperm via indirect counting of protamine-deficient sperm.
Additionally, for detection of the AT- and GC- rich chromatin regions, some chromosomal preparations were stained with the fluorochromes 4'-6-diamidino-2-phenylindole (DAPI) and chromomycin [A.
Staining with aniline blue, toludine blue, and chromomycin A3 is used to identify sperm chromatin packaging defects.
Differential fluorescent staining of porcine heterochromatin by chromomycin A3/distamycine A/DAPI and D287/170.