Additionally, there was differential expression of TGFB1 and Tp53 proteins according to the specimen histopathological diagnosis, with stronger staining in chromophobic
renal cell carcinoma type (Figures 7(g) and 7(h)).
(46) recruited 53 patients with metastatic papillary and chromophobic
renal cell carcinoma.
* Now that you're talking about the color of your memories, I think you're chromophobic
, but I don't know if it's intentional or if there's an aversion to color.
9 David Batchelor, Chromophobia (Reaktion Books, London) Speaking of color, this erudite survey of chromophobic
attitudes from antiquity to the present skillfully negotiates philosophical, art-historical, and mass-cultural allusions.
Such histologic distinctions take on an especial importance when considering that the clear cell morphology common to the renal tumors seen in von Hippel-Lindau syndrome or the chromophobic
or oncocytic features frequently noted in the renal tumors of Brit-Hogg-Dube syndrome may aid in distinguishing these entities from renal PNET.
These problems preclude its routine use in clinical practice, in that a negative biopsy does not exclude cancer, and also because of the difficulty for pathologists to distinguish between chromophobic
RCC and oncocytoma.
D: Histologic Features.--The histologic diagnosis of pituitary adenomas classifies tumors as acidophilic, basophilic, and chromophobic
using conventional stains; acidophilic adenomas were said to be associated with acromegaly or gigantism, basophilic adenomas were thought to be the cause of Cushing disease, and chromophobic
tumors were considered to be nonfunctioning from the endocrine perspective.
Most common histologies for these cancers are clear cell (80%), papillary, chromophil and chromophobic
tumours (Box 1).
When the expression of each marker was compared with the histologic tumor type, chromophobic
RCC showed the highest level of expression for all markers (Table 1).