chromosome instability syndrome

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chromosome instability syndrome

[¦krō·mə‚sōm ‚in·stə′bil·əd·ē ‚sin‚drōm]
(genetics)
Disorders due to defective DNA repair; in humans, these are marked by chromosome changes, increased risk of cancer, and other phenotypic changes.
References in periodicals archive ?
The naevoid basal-cell carcinoma syndrome (Gorlin syndrome) is a chromosomal instability syndrome, Mutat Res 397:287-292.
Among the genetic diseases with mutations in DDR genes, the chromosomal instability syndromes (CIS) are a group of rare Mendelian diseases, characterized by increased chromosome breakage resulting from unrepaired or misrepaired DNA strands breaks.
Table 1: Chromosomal instability syndromes with intrauterine growth deficiency.