Proper mitosis, in turn, depends on changes in chromosome organization, such as chromosome condensation
and sister chromatid cohesion.
Aurora kinase B also phosphorylates Ser10, along with Ser28, at the onset of mitosis to initiate chromosome condensation
Makde, a postdoctoral member of the research team led by Tan, grew molecular crystals of the protein RCC1 (regulator of chromosome condensation
, a protein critical for proper separation of chromosomes during cell division) bound to the nucleosome, and used X-ray crystallography to determine the atomic structure of the complex.
Folate sensitive fragile site expression seems to appear as a result of heritable defects of DNA methylation along a region normally binding a folding protein involved in chromosome condensation
The karyotype formula reported here are quite different from that of Wang and Guo (2007), probably reflecting variations in chromosome condensation
and/or errors in pairing and measurement.