chromosome congression
chromosome congression
[¦krō·mə‚sōm kəŋ′gresh·ən] (cell and molecular biology)
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Interestingly, CENP-E is involved in the initial alignment of chromosomes at the spindle equator on the metaphase plate, and therefore, it is required for steady spindle microtubule capture at the kinetochores, which is a critical step in proper chromosome congression during prometaphase.
Basically, siRNA-mediated CENP-E silencing results in the failure of chromosome congression to the equator, which is characterized by the clustering of chromosomes near the poles (5,6).
The presence of delayed chromosome congression was scored as a metaphase error, while the presence of anaphase bridges or lagging chromosomes was scored as an anaphase error.
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