These unstable chromosomes can also lead to ring chromosome loss
, producing monosomic cells, which may or may not be viable.
Evidence of non-random chromosome loss
in bivalves: differential chromosomal susceptibility in aneuploid metaphases of Crassostrea angulata (Ostreidae) and Ruditapes decussatus (Veneridae).
When male mice carrying the Y chromosome containing inverted loxP sites are mated with females carrying a Cre gene, chromosome loss
is induced by recombination which is mediated by Cre present between the loxP sites on sister chromatids during embryogenesis.
Lars Forsberg, who also worked on the study, said this suggested Y chromosome loss
due to smoking might be reversible
In June, Forsberg's team reported linking Y chromosome loss
to a higher risk of several types of cancer and a decreased life span in a smaller group of men.
(b) Monosomy/disomy determined from both CI within 3 standard deviations of mean (< 1.76) and SD (tumors had to show chromosome loss
by both CI and SD to be regarded as monosomic).
Subsequently non-disjunction and chromosome loss
(single or more), in these cells may lead to aneuploidy and mosaicism in cleavage and blastocyst stage embryos.
The second "bit" is the elimination of the wild-type allele through nondisjunction, deletion, recombination, and/or chromosome loss
and duplication This results in the primary mutation.
Kinetochore detection in micronuclei: an alternative method for measuring chromosome loss
. Mutagenesis 4:98-104.
Fifteen metaphases that showed no chromosome overlapping or signs of chromosome loss
were selected for karyotypic analysis.
However, genetic factors involved in this chromosome loss
or no disjunction are poorly understood.
Chromosome numbers were 2n = 100 to 106 and 2n = 111 to 119 for Dwarf1 and LCP 83-137, respectively, indicating that chromosome loss
may have contributed to the trait.