Nishioka, "Hypersensitivity of skin fibroblasts from patients with chronic actinic dermatitis to ultraviolet B (UVB), UVA and superoxide radical," Photodermatology, Photoimmunology & Photomedicine, vol.
Ferguson, "The natural history of chronic actinic dermatitis," JAMA Dermatology, vol.
PUVA is the therapeutic workhorse in chronic actinic dermatitis. An annual course of treatment, begun in the spring before solar exposure becomes more intense, is highly effective in controlling the disease.
Despite the efficacy of phototherapy in chronic actinic dermatitis, affected patients still require detailed and specific guidance regarding the necessity to avoid all substances to which they have a positive photopatch test.
Chronic actinic dermatitis
(CAD) is a severe, socially disabling and intractable photosensitive disorder particularly affecting elderly men.1 It has been shown to be a spectrum of diseases including actinic reticuloid and photosensitive eczema.2 The dermatitis is characterized by a light sensitive predominantly eczematous eruption sometimes with infiltrated plaques on the exposed areas and a tendency to progress to erythroderma, sometimes with circulating S3zary cells in severe cases.3