chylomicron


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Related to chylomicron: Chylomicron Retention Disease

chylomicron

[‚kīl·ə′mī‚krän]
(biochemistry)
One of the extremely small lipid droplets, consisting chiefly of triglycerides, found in blood after ingestion of fat.
References in periodicals archive ?
Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.
The effect of black tea on the concentrations of chylomicron remnants has not been reported.
Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation.
We have submitted this data on chylomicron handling to the EMA as part of our Marketing Authorisation Application.
183] Improved Chylomicron Clearance as a Marker for Long-Term Efficacy of Alipogene Tiparvovec (AAV1-LPLS447X Gene Therapy) in LPLD Patients Authors: Jaap Twisk, Frederique Frisch, Stephen Greentree, Harald Petry, Janneke de Wal, Diane Brisson, Claude Gagne, Andre C.
Apolipoprotein E (APOE) is a component of chylomicron remnants, VLDLs, and intermediate-density lipoproteins, and it plays critical protective roles in atherosclerosis, because recognition of APOE by LDL receptors facilitates hepatic uptake of lipoprotein remnants (29-30).
The postprandial chylomicron triacylglycerol response to dietary fat in healthy male adults is significantly explained by a combination of single nucleotide polymorphisms in genes involved in triacylglycerol metabolism.
Chylomicron remnants are rapidly cleared by liver remnant receptors, [2] as a result of apolipoprotein E (apoE) acquired in the circulation.
The IFP contains these root cells which can transform into adipocyte cells containing chylomicron and releasing leptin, chondrocyte cells synthesizing the cartilage matrix and osteoblast cells that mineralize, depending on environmental conditions.
However, more common variants in LPL, such as those examined in this study, lead to moderately decreased or increased triglycerides with chylomicron remnants and very-low-density lipoprotein remnants present in plasma.
Dietary modifications to a nonfat or medium-chain triglyceride diet have been reported as useful; refractory cases have required total parenteral nutrition and occasionally the addition of octreotide to suppress chylomicron production.
Since originally submitting the MAA, AMT has generated significant additional data, including results from a long-term efficacy study of Glybera showing that improved chylomicron metabolism could be used as a biomarker for increased LPL activity in those patients missing the gene that produces this protein.