ciguatoxin


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ciguatoxin

[¦sēg·wə¦täk·sən]
(biochemistry)
A toxin produced by the benthic dinoflagellate Gambierdiscus toxicus.
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Three samples of leftover raw barracuda and red snapper that were caught simultaneously with the barracuda that was eaten were recovered from cold storage and then tested for ciguatoxin using an experimental membrane immunobead assay at the Department of Pathology, University of Hawaii.
These lipid-soluble polyether toxins, like the ciguatoxins, exert their toxicity by activating voltage-sensitive sodium channels (1).
Fish poisoning due to ciguatoxin and scombrotoxin accounted for 73% of the outbreaks due to chemical agents.
We have previously used this paradigm to examine the developmental effects of a related polyether toxin, ciguatoxin. Through the use of microinjection, we were able to determine that the lowest observable adverse effect level of PbTx-1 was 0.8-1.0 ng/egg, which is equal to 0.8-1.0 ppm (wet weight embryo = 1.0 mg).
polynesiensis, are the primary sources of ciguatoxins (CTXs), the causative agent of ciguatera fish poisoning (CFP) (e.g., Chinain et al., 1999; Chinain et al., 2010; Holmes, 1998; Berdalet et al., 2012).
The first laboratory in Latin America and the Caribbean to be able to detect ciguatoxins, the toxins responsible for the most significant non-bacterial seafood poisoning, recently became fully operational in Cuba, the result of close cooperation between the IAEA and local partners.
(53.) Rossi F, Jullian V, Pawlowiez R, Kumar-Roine S, Haddad M, Darius HT, Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin, J Ethnopharmacol 143(1), 33-40, 2012.
Guillemin, "Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons," Neurotoxicity Research, vol.
Fish consumed by patient A at restaurant A was ruled out as the potential intoxicant vehicle because it is not commonly associated with ciguatoxin cases and was dissimilar to the other case exposures.
In order to describe the epidemiology of lionfish exposures, mechanisms of envenoming and poisoning, presenting manifestations, management, and prevention of injuries and foodborne poisonings, internet search engines, including PubMed, Medline, Ovid, Google[R], and Google Scholar[R], were queried with the key medical subject heading (MESH) words, "lionfish, envenomation; scorpionfish (Scorpaenidae), injuries; poisoning, ciguatera, ciguatoxin." Case reports, case series, epidemiological investigations, and toxicological studies were reviewed; high risk behaviors and occupations for lionfish injuries were identified; and human lionfish-inflicted injuries were stratified by their stages of progression from initial puncture to necrotic ulceration.
Ciguatera fish poisoning (CFP), the most common nonbacterial illness linked with eating fish, arises from the ciguatoxin produced by Gambierdiscus algae in tropical and subtropical areas of the Pacific, Western Atlantic, and Indian oceans.
(5) In addition, the Centers for Disease Control and Prevention reported 14 "ciguatoxin" outbreaks in the United States between 2009 and 2010.