cinchonine

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Related to cinchonine: quinine, quinidine, Cinchonidine

cinchonine

[′siŋ·kə‚nēn]

(organic chemistry)

C₁₉H₂₂N₂O A colorless, crystalline alkaloid that melts at about 245°C; extracted from cinchona bark, it is used as a substitute for quinine and as a spot reagent for bismuth.

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References in periodicals archive ?

Cinchonidine (1), cinchonine (2), quinine (3), and noscapine (narcotine, 4) are the alkaloids which are used for the treatment of biological diseases like malaria, analgesic pain, anti-inflammatory, cancer, and stroke treatment [5].

Enzyme Inhibitory and Molecular Docking Studies on Some Organic Molecules of Natural Occurrence

Together they isolated a number of alkaloids such as brucine, cinchonine, quinine, and strychnine.

Chlorophyll

Several synthetic compounds, such as verapamil (Tsuruo et al., 1981; Salmon et al., 1991), PSC833 (Boesch et al., 1991; Twentyman and Bleehen, 1991), GF120918 (Hyafil et al., 1993), LY335979 (Dantzig et al., 2001), etc., and natural products, such as the quinone alkaloids cinchonine (Genne et al., 1992), quinine (Solary et al., 1990), etc., are known to at least partially overcome P-gp mediated MDR.

Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells

A number of various other chemicals can also be synthesised from cinchona, and these include cinchonine, cinchonidine and quinidine.