cinchonine


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Related to cinchonine: quinine, quinidine, Cinchonidine

cinchonine

[′siŋ·kə‚nēn]
(organic chemistry)
C19H22N2O A colorless, crystalline alkaloid that melts at about 245°C; extracted from cinchona bark, it is used as a substitute for quinine and as a spot reagent for bismuth.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Cinchonidine (1), cinchonine (2), quinine (3), and noscapine (narcotine, 4) are the alkaloids which are used for the treatment of biological diseases like malaria, analgesic pain, anti-inflammatory, cancer, and stroke treatment [5].
Enzyme Inhibitory and Molecular Docking Studies on Some Organic Molecules of Natural Occurrence
Together they isolated a number of alkaloids such as brucine, cinchonine, quinine, and strychnine.
Chlorophyll
Several synthetic compounds, such as verapamil (Tsuruo et al., 1981; Salmon et al., 1991), PSC833 (Boesch et al., 1991; Twentyman and Bleehen, 1991), GF120918 (Hyafil et al., 1993), LY335979 (Dantzig et al., 2001), etc., and natural products, such as the quinone alkaloids cinchonine (Genne et al., 1992), quinine (Solary et al., 1990), etc., are known to at least partially overcome P-gp mediated MDR.
Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells

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