class switch


Also found in: Medical.

class switch

[′klas ‚swich]
(immunology)
A switch of B-lymphocyte expression from one antibody class to another.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The majority discontinued or decreased medication, but four subjects (19%) required a dose increase or class switch. Antianxiety data were similar to depression in that the regimen was altered in 38% of cases and the majority discontinued or decreased medication.
Ohishi et al., "Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination," Journal of Experimental Medicine, vol.
Schatz, "Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S[micro] in Ig class switch recombination," International Immunology, vol.
B cells expand their receptor repertoire by rearrangements at the Igh locus; this process involves two prominent mechanisms: V(D)J recombination in developing B cells and class switch recombination in mature B cells.
The contributors review research findings on protein tyrosine phosphatases, interleukin-21, class switch recombination, thymus organogenesis, somatic hypermutation, and T follicular helper cells.
SAFARI C(Cubed) is the only totally integrated carrier class switch that incorporates -- at no additional cost -- all of the components that make up the PacketCable(TM) voice switching infrastructure, eliminating the need for operators to purchase, maintain, upgrade and regression test separate Call Management Servers, Media Gateways, Record Keeping Servers, Announcement Servers, Signaling Gateways, Ethernet Switches and CALEA servers.
The research team led by Tasuku Honjo, a professor of molecular biology, found that a phenomenon called class switch recombination -- a genetic conversion allowing the production of antibodies by an immune cell -- can be induced in other types of cells if a special gene called AID is activated.
For example, in a process known as class switch recombination, immune cells called B cells rearrange their DNA.
They are worried by reports from secondary school heads that many youngsters who fall behind in class switch off education altogether - and then play truant from school.