classical pathway


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Related to classical pathway: alternative pathway, Complement system

classical pathway

[¦klas·i·kəl ′path‚wā]
(immunology)
The pathway by which antigen-antibody complex activates the complement system.
References in periodicals archive ?
(b) Samples were incubated with increasing concentrations of eculizumab (0-100 [micro]g/mL) and classical pathway complement activation was measured by the Wieslab[R] assay, detected as % of a normal human standard sera by the kit, defined to contain 100% activity (% of NHS).
The venom affected the classical pathway with an [IC.sub.50] of 156.6 [micro]g/mL of NHS (CI95%: 147.3- 166.6 [micro]g/mL of NHS), the alternative pathway with an [IC.sub.50] of 294.5 [micro]g/mL of NHS (CI95%: 273.2-317.4 [micro]g/mL of NHS), and the LP pathway with an [IC.sub.50] of 396.3 [micro]g/mL of NHS (CI95%: 375.7-418.0 [micro]g/mL of NHS).
Oligomeric/fibrillar A[beta] and pTau bind to C1q and activate the complement classical pathway [8-13].
The inhibitory effects of each polysaccharide's fractions and homogeneous polysaccharides on human complement activation through the classical pathway were examined.
Jass' subtypes 1 and 2 and subtype 4 reflect CRCs arising from the serrated neoplasia pathway and the classical pathway, respectively.
Classical pathway of complement is initiated by producing antibodies by natural antibodies, C-reactive protein, or serum amyloid protein [5].
Hemolytic activity in classical pathway and alternative pathway was associated with variation of the porcine genes encoding the complement components pC3 (Wimmers et al., 2003), the pC5 (Kumar et al., 2004), and the porcine mannose-binding lectin 1 (pMBL1) and pMBL2 (Phatsara et al., 2007).
As we know, the PI3-K/AKT signal pathway is a classical pathway of insulin in glucose metabolism, having a role in glucose uptake by the liver, skeletal muscles, and adipose tissues [19, 20].
Then, CRP is able to interact with C1q, activating the classical pathway of the complement system [49].
In the classical pathway UROGEN is then converted into heme via the intermediates coproporphyrinogen III, protoporphyrinogen IX, and protoporphyrin IX [2].
The classical pathway is activated by an antibody bound to a foreign particle.