clonal selection theory

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clonal selection theory

[¦klōn·əl si′lek·shən ‚thē·ə·rē]
(immunology)
Theory to explain the specificity of the adaptive immune response according to which there is a large pool of lymphocytes, each having genetically predetermined specificity for only one of a vast array of possible antigens. Upon encountering an antigen, the lymphocytes sensitive to it reproduce much more rapidly than the others, thus leading to a build-up of antigen-specific cells large enough to mount the response.
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Inspired by the clonal selection process, de Castro and von Zuben [19] propose an optimization algorithm, known as CLONALG, which exploits the cloning, mutation, and selection mechanisms of clonal selection.
MO (2013), Clonal Selection Algorithm with GEP Code for Function Modeling, Pattern Recognition & Artificial Intelligence, Chinese Association Automation, vol.26, no9, pp.878-884, 2013.
Population Diversity Optimization Based on Clonal Selection Algorithm.
Dasari et al., "Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment," Annals of Oncology, vol.
This and subsequent studies have enhanced the acceptance of xenografts as models of clonal selection and acquired resistance to therapy.
Because of vegetative propagation clonal selections are important breeding method (Lampasona et al.
The adaptive immune system has three principal processes (Timmis, Hone, Stibor, & Clark, 2008): negative selection, clonal selection and immune network.
CLONAL SELECTION ALGORITHM FOR OPTIMIZATION OF CONSTRUCTION SITE LAYOUTS.
Catalent will conduct further clonal selection and manufacturing for CiRA, and upon regulatory approval, the selected dopaminergic neurons derived from iPS cells will be transplanted into patients for a possible clinical research program.