clonal selection theory

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Related to Clonal selection: clonal expansion

clonal selection theory

[¦klōn·əl si′lek·shən ‚thē·ə·rē]

(immunology)

Theory to explain the specificity of the adaptive immune response according to which there is a large pool of lymphocytes, each having genetically predetermined specificity for only one of a vast array of possible antigens. Upon encountering an antigen, the lymphocytes sensitive to it reproduce much more rapidly than the others, thus leading to a build-up of antigen-specific cells large enough to mount the response.

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References in periodicals archive ?

In 1959, clonal selection theory was proposed by Burnet.

Optimization Model and Algorithm of Empty Pallets Dispatching under the Time-Space Network of Express Shipment

Inspired by the clonal selection process, de Castro and von Zuben [19] propose an optimization algorithm, known as CLONALG, which exploits the cloning, mutation, and selection mechanisms of clonal selection.

A Novel Immune-Inspired Shellcode Detection Algorithm Based on Hyperellipsoid Detectors

MO (2013), Clonal Selection Algorithm with GEP Code for Function Modeling, Pattern Recognition & Artificial Intelligence, Chinese Association Automation, vol.26, no9, pp.878-884, 2013.

An improved gene expression programming based on niche technology of outbreeding fusion

Population Diversity Optimization Based on Clonal Selection Algorithm.

Sliding Mode Control of Discrete Chaotic System Based on Multimodal Function Series Coupling

Dasari et al., "Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment," Annals of Oncology, vol.

Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer

This and subsequent studies have enhanced the acceptance of xenografts as models of clonal selection and acquired resistance to therapy.

Xenografts as models of clonal selection and acquired resistance to therapy

Because of vegetative propagation clonal selections are important breeding method (Lampasona et al.

Impact of Genetic Factor and Geographical Location on Allicin Content of Garlic (Allium sativum) Germplasm from Egypt and China

The adaptive immune system has three principal processes (Timmis, Hone, Stibor, & Clark, 2008): negative selection, clonal selection and immune network.

Learning faults detection by AIS techniques in CSCL environments

CLONAL SELECTION ALGORITHM FOR OPTIMIZATION OF CONSTRUCTION SITE LAYOUTS.

Clonal selection algorithm for optimization of construction site layouts

Catalent will conduct further clonal selection and manufacturing for CiRA, and upon regulatory approval, the selected dopaminergic neurons derived from iPS cells will be transplanted into patients for a possible clinical research program.