clonal selection theory


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Related to clonal selection theory: clonal selection theory of immunity

clonal selection theory

[¦klōn·əl si′lek·shən ‚thē·ə·rē]
(immunology)
Theory to explain the specificity of the adaptive immune response according to which there is a large pool of lymphocytes, each having genetically predetermined specificity for only one of a vast array of possible antigens. Upon encountering an antigen, the lymphocytes sensitive to it reproduce much more rapidly than the others, thus leading to a build-up of antigen-specific cells large enough to mount the response.
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provided some insights into the development of self-nonself identity within the immune system, and a convincing confirmation of the clonal selection theory.
Other features of the approach were based on the clonal selection theory and other immunological mechanisms.
The examples from immunology and neurology (several of which-notably the clonal selection theory of the immune response-are returned to repeatedly with different methodological lessons in view) are dealt with in increasingly fascinating depth and in masterly fashion.