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Irregular, alternating muscular contractions and relaxations.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



rhythmic contractions, in rapid succession, of single muscles or muscle groups. Clonus may be either spontaneous or provoked by external stimulation.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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A clonic seizure is rhythmic muscle jerking that generally starts in one area of the body.
However, clonic jerks time-locked with the contralateral PLEDs could be interpreted as epilepsia partialis continua (EPC).
An adequate electrical dose will manifest as generalised tonic, followed by clonic activity of skeletal muscle, accompanied by a typical seizure pattern on EEG.
The onset of clonic and tonic actions induced by PTZ in the control animals was found to be 47.80 [+ or -] 1.69 and 72.60 [+ or -] 1.78 s, respectively.
The established drugs for treatment of partial and generalized tonic clonic seizures are carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), primidone (Mysoline) and valproate (Depakote).
Study title: An Open-Label Study to Evaluate the Safety, Tolerability, and Exposure-Efficacy Relationship of Fycompa Oral Suspension When Administered as an Adjunctive Therapy in Pediatric Subjects (Age 4 to Less Than 12 Years) With Inadequately Controlled Partial-Onset Seizures or Primary Generalized Tonic Clonic Seizures
Apparently her antenatal period was uneventful till she developed seizures, which were tonic and clonic in nature, associated with tongue bite and frothing from mouth.
The mice were closely monitored during a 30-minute period following the injection of PTZ, and the latency times to the onset of myoclonic, clonic, and tonic convulsions were recorded.