cobalamin


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cobalamin:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.
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cobalamin

[kə′bȯl·ə·mən]
(biochemistry)
vitamin B12
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Vitamin B12 (Cobalamin, Cyanocobalamin) Product Types In-Depth: Cyanocobalamin Injection, Cyanocobalamin Oral & Cyanocobalamin Spray
We also constructed a receiver operative curve (ROC curve) to investigate the suitability of serum cobalamin as a predictive biomarker for GDM.
Guidelines for the diagnosis and treatment of cobalamin and folate disorders.
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
Describe the metabolites that are increased in inherited intracellular vitamin [B.sub.12] (cobalamin) defects.
Fu, "Clinical characteristics of hemolytic uremic syndrome secondary to cobalamin C disorder in Chinese children," World Journal of Pediatrics, vol.
Cobalamin has been shown to reduce the bioactivity of NO, as NO will bind to the corrin ring structure of cobalamin [14].
The following was assessed: folate, cobalamin, and total homocysteine concentrations.
Cobalamin deficiency induced TMA poses a diagnostic hurdle for clinicians encountering patients presenting with thrombocytopenia, hemolytic anemia, and schistocytosis.
(2) In children, for example, mutations in the gene encoding the methylmalonic aciduria and homocystinuria type C (MMACHC) have been identified that result in abnormal cobalamin C metabolism, termed cobalamin C disease, which in turn has been associated with endothelial dysfunction, platelet activation, coagulation cascade activation, and increased expression of tissue factor.
The standard reaction mixture contained 100 mM potassium phosphate, pH 7.2,500 [micro]M homocysteine, 152 [micro]MSAM, 2 mM titanium citrate, 250 [micro]M (6R,S)-5-[[sup.14]C]methyltetrahydrofolate (GE Healthcare), 50 [micro]M of the specified cobalamin, and cell extract in a final volume of 1 mL.
It was reported that cobalamin had potent superoxide scavenging ability.