What is biologically plausible depends upon the biological knowledge of the day." By now there are studies showing a cocarcinogenic
and tumour-promoting effect from RF radiation.
Our report suggests the need to be cautious in regard to the use of BJ as well as to perform research about the possible comutagenic and cocarcinogenic
effects between the juice and AOM, incorporating a number of factors, some of which have already been suggested in the above-mentioned reports, such as the influence of different doses, differences in strain sensibility, and the participation of the juice and its components in the molecular events involved in the precarcinogenesis process, as various genetic/epigenetic changes have a role in the transformation of a single epithelial cell within the crypt to the AC formation.
Below, the main findings of these studies are reviewed for the benefit of the new readership, to highlight the experimental work providing strong evidence in support of a putative etiopathogenic cocarcinogenic
role of SV40 in MM, despite the data from molecular and epidemiologic analyses showing moderately strong but controversial association.
Although the exact mechanisms through which alcohol exerts its cocarcinogenic
effect on the breast remain unknown, a genetic predisposition may play an important role.
Active HSV-1 immunization prevents the cocarcinogenic
activity of HSV-1 in the oral cavity of hamsters.
Hecker E (1968) Cocarcinogenic
principles from the seed oil of Croton tiglium and from other Euphorbiaceae.
Among the reasons cited for the beneficial role of fruit and vegetables in this area are that dietary fibre decreases the body's production of secondary bile acids which have been found to be cocarcinogenic
in tests conducted on rodents.
Still other components in ETS are either cocarcinogenic
tumor initiators or tumor accelerants.
effects of alcohol in hepatocarcinogenesis.
Vitamin E and organose-lenium prevent the cocarcinogenic
activity of arsenite with solar UVR in mouse skin.
These data provide further evidence to support the ability of As to inhibit the DNA repair machinery, which is likely to enhance the genotoxicity and mutagenicity of other directly genotoxic compounds, as part of a cocarcinogenic
mechanism of action.
(1999) found no evidence for a cocarcinogenic
or tumor-promoting effect of MF exposure, but the study used different substrains of SD rats than used in the original study.