cofactor

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cofactor

[′kō‚fak·tər]

(biochemistry)

A specific substance required for the activity of an enzyme, such as a coenzyme or metal ion.

(mathematics)

References in periodicals archive ?

Subsequently, this glutamate serves as a nitrogen donor to be distributed into the monomers and multimers predominantly through transamination reactions enabled by the cofactor pyridoxal phosphate.

Analysis of the intermediary metabolism of a reductive chemoautotroph

CoFactor (ANX-510) is a folate-based biomodulator drug designed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-fluorouracil (5-FU).

ADVENTRX Begins Phase II Clinical Trial of Breast Cancer Treatment

Human papillomavirus (HPV) is well established as an infection that is central to the pathogenesis of invasive cervical cancer, but because many women with HPV do not develop this cancer, it is believed certain cofactors play a role in disease development.

HSV-2 is deemed not a cofactor in cervical cancer

Other possible regulatory factors include the presence of termination inhibitors or enhancers or a regulatory role of the magnesium cofactor.

Biotechnological development of domestic rubber producing crops

To control part of the genetic background by reducing the segregation variance generated by linked and unlinked QTLs, when the analysis is performed for a given position in the linkage map, appropriate markers outside of the interval analyzed can be fitted as cofactors in models [3] and [5].

A haplotype-based method for QTL mapping of [F.sub.1] populations in outbred plant species

(1.) Smith JS et al., Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer, Journal of the National Cancer Institute, 2002, 94(21):1604-1613.

Cervical cancer risk rises if women HPV also have herpes infection. (Digests)

Even so, although a matrix may not be a QI matrix, many of the arrays corresponding to its cofactors can be.

Topics in Nonparametric Comparative Statics and Stability

Carnitine supplementation is the best understood type of cofactor therapy.

Total parenteral nutrition

This is especially true for the subset of metalloenzymes that utilise a redox-active metal cofactor such as manganese (Mn) or iron (Fe).

How is cofactor specificity determined in metalloenzymes

It provides the cofactor function of factor VIII in people with hemophilia A, who either lack or have impaired coagulation function of factor VIII.

EC approves Chugai's Hemlibra in people with haemophilia A with inhibitors

US-based RNA products and applications specialist Cofactor Genomics has acquired US-based Narus Biotechnologies, a biomarker development company focused on creating RNA diagnostic tests for neurological diseases, the Cofactor said.

Deal snapshot: COFACTOR GENOMICS ACQUIRES RNA DIAGNOSTIC TEST DEVELOPER

The detailed reactions of each of these enzymes are not the subject of this article, but single nuclear polymorphisms or cofactor deficiencies could lead to poor tetrahydrobiopterin (BH4) status.