cofactor


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cofactor

[′kō‚fak·tər]
(biochemistry)
A specific substance required for the activity of an enzyme, such as a coenzyme or metal ion.
(mathematics)
References in periodicals archive ?
Subsequently, this glutamate serves as a nitrogen donor to be distributed into the monomers and multimers predominantly through transamination reactions enabled by the cofactor pyridoxal phosphate.
CoFactor (ANX-510) is a folate-based biomodulator drug designed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-fluorouracil (5-FU).
Human papillomavirus (HPV) is well established as an infection that is central to the pathogenesis of invasive cervical cancer, but because many women with HPV do not develop this cancer, it is believed certain cofactors play a role in disease development.
Other possible regulatory factors include the presence of termination inhibitors or enhancers or a regulatory role of the magnesium cofactor.
To control part of the genetic background by reducing the segregation variance generated by linked and unlinked QTLs, when the analysis is performed for a given position in the linkage map, appropriate markers outside of the interval analyzed can be fitted as cofactors in models [3] and [5].
(1.) Smith JS et al., Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer, Journal of the National Cancer Institute, 2002, 94(21):1604-1613.
Even so, although a matrix may not be a QI matrix, many of the arrays corresponding to its cofactors can be.
Carnitine supplementation is the best understood type of cofactor therapy.
This is especially true for the subset of metalloenzymes that utilise a redox-active metal cofactor such as manganese (Mn) or iron (Fe).
It provides the cofactor function of factor VIII in people with hemophilia A, who either lack or have impaired coagulation function of factor VIII.
US-based RNA products and applications specialist Cofactor Genomics has acquired US-based Narus Biotechnologies, a biomarker development company focused on creating RNA diagnostic tests for neurological diseases, the Cofactor said.
The detailed reactions of each of these enzymes are not the subject of this article, but single nuclear polymorphisms or cofactor deficiencies could lead to poor tetrahydrobiopterin (BH4) status.