cofactor


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cofactor

[′kō‚fak·tər]
(biochemistry)
A specific substance required for the activity of an enzyme, such as a coenzyme or metal ion.
(mathematics)
References in periodicals archive ?
Cofactor Genomics uses RNA to help researchers and clinicians understand, diagnose, and predict drug response for the 95% of disease that can't be assessed by DNA alone.
The structure of FeMo cofactor and the product when it reacted with nitrogen are developed and is shown in Fig.
Nitrate reductase requires cofactors to function, which leads us to three important interactions.
In order for these reactions to occur suitably, the enzymes and cofactors that regulate their flow must be present in the proper balance.
Note that a Darboux polynomial with zero cofactor is a polynomial first integral.
The possible exceptions, histidinal and histinidol, may have resulted from components of a vestigial cofactor pathway.
Other chapter topics are structure and function of [NiFe]-hydrogenases, carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases, the dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide, copper-carbon bonds in mechanistic and structural probing of proteins, and computational studies of bioorganometallic enzymes and cofactors.
Collectively, our results establish the diet-dependent influence of Pparg2 Pro12Ala variant on metabolic control via modulated cofactor interaction and changes in gene expression patterns in mice," concluded the researchers.
The biotechnology company's cancer-drug candidate CoFactor failed to meet its goal in a midstage study.
Other experiments will utilize aldo-keto reductases that utilize NADPH as a cofactor.
today announced the initiation of a Phase II clinical trial using CoFactor in the treatment of refractory metastatic breast cancer.