colchicine

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colchicine

colchicine (kŏlˈchəsēnˌ), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffron). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosis, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drug. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]

(organic chemistry)

C₂₂H₂₅O₆N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.

References in periodicals archive ?

However, the colchicine group showed improvement on the Homeostatic Model Assessment of Insulin Resistance test.

Gout Drug May Reduce Risk for Type 2

The objective of this study was to evaluate the efficacy and safety of canakinumab, a fully human anti-IL-1[beta] monoclonal antibody, that binds to human IL-1[beta] and neutralizes its proinflammatory effects, in patients with FMF who are resistant or intolerant to higher doses of colchicine.

Treatment of familial mediterranean fever with canakinumab in patients who are unresponsive to colchicine

All patients achieved remission after conservative medical therapy, most commonly with corticosteroids in 36 (77%) patients, and with nSAids or colchicine in 11 (23%) patients.

POSTPERICARDIOTOMY SYNDROME INCIDENCE, DIAGNOSTIC AND TREATMENT STRATEGIES: EXPERIENCE AT TWO COLLABORATIVE CENTERS

The current US market for colchicine products is approximately USD 800m.

Romeg Therapeutics Receives FDA Approval of Gloperba for Prophylaxis of Adult Gout Flares

This study used a split-mouth design to study ligated groups with or without systemic administration of colchicine, with the experimental conditions on one side, and the control on the other.

The effect of colchicine on alveolar bone loss in ligature-induced periodontitis

As a result of studies on Colchicum species, the substance named Colchicine was found in the structure.

The Antiproliferative Activity of Colchicum umbrosum Plant Extract and Paclitaxel on C-41 and Vero Cells

The patient exhibited spontaneous pattern myalgia findings, and the symptoms did not respond to resting or taking NSAIDs, and lasted longer (six to seven days on average), contrary to what is reported in the literature.[8] Based on the MEFV mutation analysis showing a homozygous M694V mutation, colchicine treatment was initiated to relieve FMF-induced symptoms, and the patient responded to the treatment well.

Familial Mediterranean fever with recurrent erysipelas-like erythema and myalgia: A case report

Production of amphidiploid plants of interspecific hybrid genotypes: Both stem axillary buds and shoot tips of in vitro grown plantlets of interspecific hybrid genotypes were cultured in 90x15mm Petri dishes on solidified MS medium supplemented with 0.03% colchicine and 0.225 mg L-1 BA, for 3 or 6 days.

PRODUCTION OF DIPLOID AND AMPHIDIPLOID INTERSPECIFIC HYBRIDS OF EGGPLANT AND SOLANUM TORVUM, AND POLLEN FERTILITY

After giving their informed consent and completing a baseline questionnaire, patients were randomized to receive either naproxen as a single 750-mg dose, then as 250 mg three times a day for a maximum of seven days, which is the licensed dose for gout in the United Kingdom, or 500 mcg of colchicine three times a day for four days.

Naproxen supported over low-dose colchicines for gout

All patients were in remission and on colchicine treatment.

Evaluation of Dynamic Postural Balance in Pediatric Familial Mediterranean Fever Patients

That hint of efficacy in just three patients 23 years ago forms the sole basis of the typical treatment for this disorder: colchicine, Dr.

Dual studies seek answers in isolated skin vasculitis

Therapeutic options include tumor necrosis factor-a inhibitors, interferon-a, apremilast, and traditional treatments such as corticosteroids, non-steroidal anti-inflammatory drugs, colchicine, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, cyclophosphamide, thalidomide, methotrexate, and dapsone (9).