colchicine


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colchicine

(kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffronmeadow saffron
or autumn crocus,
perennial garden ornamental (Colchicum autumnale) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
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). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosismitosis
, process of nuclear division in a living cell by which the carriers of hereditary information, or the chromosomes, are exactly replicated and the two copies distributed to identical daughter nuclei.
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, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drugimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
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. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]
(organic chemistry)
C22H25O6N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.
References in periodicals archive ?
However, the colchicine group showed improvement on the Homeostatic Model Assessment of Insulin Resistance test.
The objective of this study was to evaluate the efficacy and safety of canakinumab, a fully human anti-IL-1[beta] monoclonal antibody, that binds to human IL-1[beta] and neutralizes its proinflammatory effects, in patients with FMF who are resistant or intolerant to higher doses of colchicine.
All patients achieved remission after conservative medical therapy, most commonly with corticosteroids in 36 (77%) patients, and with nSAids or colchicine in 11 (23%) patients.
The current US market for colchicine products is approximately USD 800m.
This study used a split-mouth design to study ligated groups with or without systemic administration of colchicine, with the experimental conditions on one side, and the control on the other.
As a result of studies on Colchicum species, the substance named Colchicine was found in the structure.
The patient exhibited spontaneous pattern myalgia findings, and the symptoms did not respond to resting or taking NSAIDs, and lasted longer (six to seven days on average), contrary to what is reported in the literature.[8] Based on the MEFV mutation analysis showing a homozygous M694V mutation, colchicine treatment was initiated to relieve FMF-induced symptoms, and the patient responded to the treatment well.
Production of amphidiploid plants of interspecific hybrid genotypes: Both stem axillary buds and shoot tips of in vitro grown plantlets of interspecific hybrid genotypes were cultured in 90x15mm Petri dishes on solidified MS medium supplemented with 0.03% colchicine and 0.225 mg L-1 BA, for 3 or 6 days.
After giving their informed consent and completing a baseline questionnaire, patients were randomized to receive either naproxen as a single 750-mg dose, then as 250 mg three times a day for a maximum of seven days, which is the licensed dose for gout in the United Kingdom, or 500 mcg of colchicine three times a day for four days.
That hint of efficacy in just three patients 23 years ago forms the sole basis of the typical treatment for this disorder: colchicine, Dr.
Therapeutic options include tumor necrosis factor-a inhibitors, interferon-a, apremilast, and traditional treatments such as corticosteroids, non-steroidal anti-inflammatory drugs, colchicine, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, cyclophosphamide, thalidomide, methotrexate, and dapsone (9).