TNT009 is currently in clinical development for the treatment of Cold Agglutinin
Disease (CAD), a rare disease in hematology.
A When we have encountered a patient with a cold agglutinin
and rewarming the sample does not correct the problem, we have employed a technique of replacing the plasma with warm isotonic diluent used by our analyzers.
This should be contrasted with cold agglutinins
which cause agglutination of RBCs.
An increase in cold agglutinin
titers is frequently observed during M.
On the other hand, cold agglutinin
disease/cold antibody AIHA are included in the category u disease group; therapeutic plasma exchange is recommended alone or in combination with other treatments as the second-line treatment in this group of diseases according to the guidelines of the American Society for Apheresis (ASFA) Apheresis Applications Committee, published in 2016 (6).
A histogram distribution that is bimodal can be seen in various situations, such as dimorphic anemia, cold agglutinin
disease, after the transfusion of normal erythrocytes into a person with abnormally sized erythrocytes, in the presence of erythrocyte fragments, or with agglutination.
The cold agglutinin
titre was not significant with adult cells, cord cells, and patient's cells.
Mycoplasma pneumonia is a very small bacterium in the class Mollicutes and is related to cold agglutinin
The female patient in Italy with AOSD, at the onset of her illness developed autoimmune haemolytic anaemia due to cold agglutinin
. Whereas in Japan a 37-year-old woman with autoimmune haemolytic anaemia (AIHA) was diagnosed as having adult-onset Still\'s disease (AOSD).
Many can be avoided at the bench by astute technologists who sequester distorted indices generated by samples taken from patients with obvious hypertriglyceridemia or cold agglutinin
AIHA refers to both cold agglutinin
disease and warm autoimmune hemolytic anemia.
In a five-year-old female patient who developed cold agglutinin
disease after acute gastroenteritis, recovery could not be achieved with steroid and IVIG treatment and need for transfusion was eliminated following a single application of plasmapheresis (4).