cold agglutinin

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cold agglutinin

[′kōld ə′glüt·ən·ən]
(immunology)
A nonspecific panagglutinin found in many normal human serums which produce maximum clumping of erythrocytes at 4°C and none at 37°C.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In the case presented by the authors, IgM type autoantibodies lead to agglutination and hemolysis of erythrocytes by adhering to erythrocyte surface with complement (C3b) opsonization at low temperature (3-4 [degrees]C) in cold antibody AIHA (cold agglutinin disease) which the authors were focused on and which frequently occurs secondary to infections (1, 2, 4, 5).
Because of the high cost of commercial anti-hAXL antibody, we did not include cold antibody as the blocking agent for microPET/CT imaging.
Aside from prewarming the specimens, circumventing an offending cold antibody can be done by using 22% bovine serum albumin instead of low ionic-strength solutions because some cold RBC autoantibodies are enhanced by low ionic-strength solutions.
Successful Treatment of a Patient with Mixed Warm and Cold Antibody Mediated Evans Syndrome and Glucose Intolerance.
Petz, "Cold antibody autoimmune hemolytic anemias," Blood Reviews, vol.