In collagen vascular diseases
, such as scleroderma, where apparent autoimmune inflammation of collagen occurs, would supplementation exacerbate the disease by bringing about more collagen to attack, or would it improve the condition by providing new collagen where there may be a defect?
Their topics include immune response overview, the anatomic classification of uveitis, cataract-inducted and lens-induced uveitis, intermediate uveitis, posterior uveitis and collagen vascular diseases
, white dot syndrome, AIDS-related eye disease, drug induced uveitis, and the treatment of uveitis.
While diffuse pleural thickening is commonly associated with exposure to commercial forms of asbestos, it can also be caused by collagen vascular diseases
(systemic lupus erythematosus, rheumatoid arthritis), drugs (methysergide and chemotherapy), infection (TB or chronic fungal), and sarcoidosis and can also be idiopathic in nature.
We know that the clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular diseases
such as scleroderma, and a pathophysiological link between autoimmune conditions and chronic GVHD may be present.
In the lung, DAH most commonly occurs in the setting of microscopic polyangiitis but may also occur in the setting of collagen vascular diseases
, anti-glomerular basement membrane antibody syndrome (Goodpasture syndrome), and anti-phospholipid antibody syndrome, among other immune disorders.
Other causes include infections (tuberculosis, syphilis, osteomyelitis, and pneumonia), systemic vascularities (HughesStovin's disease, Behcet's disease), collagen vascular diseases
, connective tissue disorders, inherited disorders (Marfan's syndrome, Ehlers-Danlos syndrome), trauma (direct or blunt chest injury), mucoid vasculopathic changes, and idiopathic PAA.
The common causes for raised eosinophil count are parasitic conditions, allergy/atopy, eczema, urticaria, allergic rhinitis, angioneurotic oedema, reactive eosinophilia subsequent to T-cell lymphoma, B-cell lymphoma, acute lymphoblastic leukemia, eosinophilic leukemia, idiopathic hypereosinophilic syndrome, allergic drug reactions and collagen vascular diseases
such as rheumatoid arthritis, eosinophilic fasciitis or allergic angiitis.
(1) Genetic syndromes and collagen vascular diseases
are another potential source of multiple aneurysms in children, and include entities such as Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, thoracic aortic aneurysm and dissection (TAAD), as well as Turner syndrome, neurofibromatosis, and autosomal dominant polycystic kidney disease (ADPKD).
Serologic tests to rule out SLE and other collagen vascular diseases
showed antinuclear antibody (ANA) levels of 180 AU/mL (> 25 positive) and anti-double-stranded DNA (anti-dsDNA) of 260 IU/mL (> 100 positive).
However ILD are difficult to classify because approximately 150plus known diseases are characterized by interstitial involvement, either as a primary disease or as a part of multi organ process as may occur in collagen vascular diseases
one useful approach is to separate ILD into two groups, those with known or unknown causes, for each ILD there may be an acute phase followed by a phase of chronicity with acute exacerbation.
Splenic infarction is mostly found during cases of the most common hematologic diseases, including sickle cell anemia, bacterial endocarditis, hematologic malignancy, cardiac embolism, hypercoagulability, splenic vascular diseases, myelofibrosis, sarcoidosis, amyloidosis, pancreatitis, collagen vascular diseases
, and non-hematological neoplastic diseases.
The switch from upregulation of iNOS in endothelial and smooth muscle cells is not unique to SSc, having been described in other collagen vascular diseases