The mechanical movement of the mites through the hair follicles and meibomian glands caused severe irritation, the persistent cutting and feeding of the mite on the epithelium of hair follicles and main collecting tubules of the meibomian glands and their secretions, excretions, and somatic debris resulted in inflammation and dilatation of the orifices of the hair follicles and main collecting tubules of the meibomian glands.
(41) Histologically there is diffuse acute tubular injury accompanied by uric acid crystals located predominantly in the collecting tubules. In formalin-fixed tissue, urate crystals are largely dissolved in processing, leaving behind empty lacunae.
Homeostatic control of sodium excretion is achieved via changes in sodium reabsorption in the late distal and collecting tubules. This requires some explanation since more than 90% of the filtered sodium is reabsorbed before the filtrate even reaches these nephron segments.