PDAs with neoplastic mucin cyst or colloid carcinoma
may mimic mucinous cystic neoplasm or IPMN with an associated invasive carcinoma.
(5,7,11-13) Agackiran et al (7) reported positive staining in 70% (7 of 10) of the mucinous tumors included in their study, including 4 of 4 colloid carcinomas
and 3 of 6 MAs, whereas Chu et al (13) reported 16 pulmonary MAs that were negative for napsin A.
(60) The supposition is that once colloid carcinoma
cells overcome the protective barrier created by the mucin and infiltrate into the stroma as individual cells, they acquire (or reflect) an aggressive behavior that practically negates the survival advantage seen in pure colloid carcinomas
Because SPCs are commonly associated with invasive mucinous carcinoma, they were originally considered precursors of colloid carcinomas
. (1,2) However, their association with other variants of ductal carcinomas and their frequent neuroendocrine differentiation suggest that they are probably heterogeneous tumors.
Value of fine needle aspiration cytology of the breast, with an emphasis on the cytodiagnosis of colloid carcinoma
. Acta Cytol.
Pathogenesis of colloid (pure mucinous) carcinoma of exocrineorgans: coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma
in the breast and pancreas.
(3,16,23,52,53) Lastly, colloid carcinoma
is another example of metastatic adenocarcinoma with unique histologic features that suggest a particular differential diagnosis of primary site.
.--Colloid carcinoma consisting of tumor with pools of extravasated mucin is another area of grading controversy.
Some have a signet ring component, as seen in our case, and others have the morphology of colloid carcinomas
Mucinous carcinomas, also called colloid carcinomas
, are most common in older women, associated with a good prognosis these lesions comprise 1-7% of invasive breast cancers.
Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas
, undifferentiated carcinomas and undifferentiated carcinomas with osteoclast like giant cells.