combinatorial chemistry


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combinatorial chemistry

[kəm‚bīn·ə¦tȯr·ē·əl ′kem·ə·strē]
(organic chemistry)
A method for reacting a small number of chemicals to produce simultaneously a very large number of compounds, called libraries, which are screened to identify useful products such as drug candidates.
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It is not, however, impossible if we use combinatorial chemistry technology.
Newman adds that combinatorial chemistry has produced plenty of variations on known medicinal compounds.
Consumables will remain the largest group of combinatorial chemistry products, with demand advancing 14 percent annually through 2006.
Combinatorial chemistry can best be described as a collection of modern technologies that has spawned a rebirth of medicinal, organic and pharmaceutical chemistry in academic, biotechnological and pharmaceutical company settings.
The current popularity of combinatorial chemistry came about when the various component technologies of miniaturization, automation techniques and data processing power reached a point where they became useful at the same time that the pharmaceutical industry was experiencing enormous pressure to speed up the process of drug discovery.
The basic concept of combinatorial chemistry is to make a large number of chemical variants in parallel, to then screen them quickly and reliably for chemical activity, and to build a library of information about the results of this designed/random chemical diversity.
Large pharmaceutical firms are looking at combinatorial chemistry as critical to their own drug discovery strategies.
In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others.
Combinatorial chemistry has increased production within the pharmaceutical industry at an exponential rate, and this textbook for chemistry and pharmaceutical students and researchers explains the automated sample preparation and analysis that is required to process these advances.
By combining MitoKor's unique platform in mitochondrial biology with Mimotopes' advanced technology in combinatorial chemistry, solid phase synthesis and novel polymer systems, the company intends to form a fully integrated drug discovery company.
The idea of chemistry chips began as a response to two research trends: genomics and combinatorial chemistry, says Michael R.
Accord SDK is a programming toolkit which allows users to develop applications addressing problems as diverse as combinatorial chemistry, property prediction, and database publishing.
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