Clinical utility of array comparative genomic hybridization
for prenatal diagnosis:a cohort study of 3171 pregnancies.
Naito, "Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: Molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization
," Journal of Experimental & Clinical Cancer Research, vol.
Comparative genomic hybridization
data, comparing pleomorphic LCIS to classic LCIS, show that although there are some shared alterations, including loss of 16q, gain of 1q, and loss of 17p, pleomorphic LCIS showed additional recurrent alterations not observed in classic LCIS.
In this paper we have shown that comparative genomic hybridization
provides completely different insight into chromosomal aberrations in preimplantation embryos.
Miller et al., "Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization
correlates with loss of heterozygosity and fluorescence in situ hybridization," The Journal of Molecular Diagnostics, vol.
Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization
in multiple myeloma.
Sudar et al., "Comparative genomic hybridization
for molecular cytogenetic analysis of solid tumors," Science, vol.
(9.) Guled M, Myllykangas S, Frierson Jr HF, et al: Array comparative genomic hybridization
analysis of olfactory neuroblastoma.
In order to overcome these limitations, molecular genetic methods such as fluorescence in situ hybridization (FISH), quantitative real-time polymerase chain reaction (Q-RT-PCR), and array comparative genomic hybridization
(CGH) have emerged for diagnosis of hematologic malignancies (4), (5).
Oxford Gene Technology's CytoSure Cancer +SNP array combines long oligo array comparative genomic hybridization
(aCGH) probes with fully validated single nucleotide polymorphism (SNP) content, providing enhanced detection of both copy number variations and loss of heterozygosity on a single chip.