comparative genomic hybridization


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comparative genomic hybridization

[kəm¦par·əd·iv jə‚nō·mik ‚hī·brəd·ə′zā·shen]
(genetics)
A method that uses fluorescence in situ hybridization and comparison of the strength of hybridization signal to determine any differences in copy number of deoxyribonucleic acid sequences anywhere in the nuclear genome.
References in periodicals archive ?
Naito, "Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: Molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization," Journal of Experimental & Clinical Cancer Research, vol.
Comparative genomic hybridization data, comparing pleomorphic LCIS to classic LCIS, show that although there are some shared alterations, including loss of 16q, gain of 1q, and loss of 17p, pleomorphic LCIS showed additional recurrent alterations not observed in classic LCIS.
Miller et al., "Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization," The Journal of Molecular Diagnostics, vol.
Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma.
Sudar et al., "Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors," Science, vol.
(9.) Guled M, Myllykangas S, Frierson Jr HF, et al: Array comparative genomic hybridization analysis of olfactory neuroblastoma.
Introducing array comparative genomic hybridization into routine prenatal diagnosis practice: a prospective study on over 1000 consecutive clinical cases.
In order to overcome these limitations, molecular genetic methods such as fluorescence in situ hybridization (FISH), quantitative real-time polymerase chain reaction (Q-RT-PCR), and array comparative genomic hybridization (CGH) have emerged for diagnosis of hematologic malignancies (4), (5).
Oxford Gene Technology's CytoSure Cancer +SNP array combines long oligo array comparative genomic hybridization (aCGH) probes with fully validated single nucleotide polymorphism (SNP) content, providing enhanced detection of both copy number variations and loss of heterozygosity on a single chip.
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
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