competitive inhibition


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Related to competitive inhibition: Uncompetitive inhibition

competitive inhibition

[kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration.
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To investigate whether materials present in the cDNA reaction mixture inhibited another RT-PCR step, competitive inhibition PCR was carried out with mixtures of cDNA templates prepared from the same amount of hepatopancreatic RNA isolated using methods I and III.
French, "An improved competitive inhibition enzymatic immunoassay method for tetrodotoxin quantification," Biological Procedures Online, vol.
(2) Secondly, one should recognize the potential CYP3A4 competitive inhibition when using RTV and an azolic agent.
Mechanism of this syndrome is metabolism of tramadol in liver by hydroxylation and conjugation with glucuronide which leads to metabolism of SSRI via competitive inhibition. In this patient, we observed that tramadol can individually cause SS (including restlessness, autonomic disorders, and neurological symptoms).
This causes competitive inhibition of leukotrienes which subsequently blocks the inflammatory effects of leukotrienes.
Conclusion: Overall, this was the first investigation of the inhibitory effects of MA on CYP1A2 and CYP2B6 in HLMs, and it has identified that MA acts via competitive inhibition.
Through passive transport, diffusion, and active transport, they deliver serotonin and dopamine to the body in a competitive inhibition manner.
Therefore, competitive inhibition of the activation of TGF-[beta] through treatment with M6P is considered another method by which M6P may inhibit fibrosis.
Several amino acids, such as phenylalanine (Phe), have been reported to reduce melanin formation through competitive inhibition of tyrosinase or by reducing tyrosinase uptake [20, 21].
Nonlinear regression was used to calculate the inhibition kinetic parameters (Kf according to the equations for competitive inhibition (1) and noncompetitive inhibition (2):
The competitive inhibition found can be explained by the fact that methanolic and aqueous extracts possess compounds with similar functional groups to those of the substrate starch, which has moved from the active site of the enzyme.
(2010) have recorded the seroprevalence as 26percent in semi-arid, sweet and sour rangeland of South Africa using competitive inhibition ELISA.

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