competitive inhibition

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competitive inhibition

[kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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However, nociceptin avoidance in Tetrahymena thermophila is blocked by addition of J-113397, a competitive inhibitor of the vertebrate nociceptin receptor.
Narezode (6-methylpyrazole) is a known competitive inhibitor of alcohol dehydrogenase (12-14) that could substitute for ethanol in the treatment of EG poisoning.
Khan and Atta-Ur-Rahman, Kinetics of Novel Competitive Inhibitors of Urease Enzymes by a Focused Library of Oxadiazoles / Thiadiazoles and Triazoles, Biochem.
In this study, it is clear from the in vitro inhibition kinetic studies in rat liver microsomes that MA can act as competitive inhibitor to rat CYP2C11 with a of 98.7 [micro]M.
"Carnosine has been shown to act as a competitive inhibitor of the non-enzymatic glycosylation of proteins," Babizhayev and colleague A.
Perchlorate is a competitive inhibitor of the sodium iodide symporter, the thyroid cell-surface protein responsible for transporting iodide from the plasma into the thyroid.
Whereas protein methylation appears to be important in RNA binding and protein sorting, ADMA evolved as a competitive inhibitor of nitric oxide synthase at the arginine-binding site (1, 2).
Like several other HIV drugs, Sustiva is both an inducer and competitive inhibitor of the cytochrome P450 CYP3A4 isoenzyme.
Trovagene refers to NMS-1286937 as PCM-075, which is an oral, investigative drug and a highly-selective adenosine triphosphate (ATP) competitive inhibitor of the serine/threonine polo-like-kinase 1 (PLK 1).
Perindoprilat is a potent competitive inhibitor of ACE the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
A non competitive inhibitor may bind to the allosteric site of the enzyme and not necessarily bind to the active site of the enzyme.
Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear.

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