complement fixation


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Related to complement fixation: Complement system

complement fixation

[′käm·plə·mənt ‚fik′sā·shən]
(immunology)
The binding of complement to an antigen-antibody complex so that the complement is unavailable for subsequent reaction.
References in periodicals archive ?
The complement fixation method is more sensitive than the immunodiffusion test and presents variable test sensitivity, depending on the antigen phase, ranging from 72.
Because hyphal forms are rarely encountered in tissue, a correlation between complement fixation titers and immunodiffusion result patterns has not been established in the literature.
Evidence supporting complement fixation as the basis of ENL reactions is essentially indirect, derived from patients' sera and biopsied tissues.
of cases) California (25) Arizona (2) Texas (1) Common symptoms: recent chest pain, shortness of breath Positive Negative Coccidioidin skin test 6 14 Complement fixation serology 29 1 Coccidioides spp culture 29 2 Surgical procedures (No.
Progressive loss of efficiency and fatal outcome resulting in massive economical losses forced veterinary authorities worldwide to start disease control including mass testing using complement fixation test and/or malleinisation, and culling of positives.
Complement fixation for Coccidioides was attempted but was non-diagnostic due to anti-complement activity.
For the investigation of fever of infectious origin, brucellosis, leptospirosis, toxoplasmosis, HTLV1, HTLV2, and viral hepatitis types A, B, C were investigated, and ELISA method was used for all research; for mononucleosis, another two samples were collected, and the method used was Hoff and Bauer; for leishmaniasis and paracoccidioidomycosis the technique of complement fixation reaction was used; for Chagas disease, immunofluorescence was used; for cytomegalovirus, chemiluminescence was used.
capsulatum, Blastomycosis dermatitidis, and Paracoccidioides brasiliensis by using complement fixation and immunodiffusion.
It may be safe if patients continue fluconazole and as long as their complement fixation titer remains negative.
On a serum specimen obtained about 10 days after onset of symptoms, a complement fixation test was positive at 1:8, and immunodiffusion for IgM and IgG were both negative (Mayo Medical Laboratories, Rochester, MN).
EVALUATIONS/MEASUREMENTS: We defined a case by positive immunodiffusion serology, a [greater than or equal to] 4-fold titer rise in complement fixation between acute and convalescent sera, or positive urinary Histoplasma capsulatum (HC) antigen.

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