complement fixation


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Related to complement fixation: Complement system

complement fixation

[′käm·plə·mənt ‚fik′sā·shən]
(immunology)
The binding of complement to an antigen-antibody complex so that the complement is unavailable for subsequent reaction.
References in periodicals archive ?
This method is more specific than the complement fixation (2,3) and presents the following strengths: (i) it is based on simple and reliable methodology; (ii) it has a low cost; (iii) specificity is close to 70-100%.
Antibodies against Varicella virus were detected using complement fixation test (CFT) and Immunoglobulin M (IgM) by ELISA.
Serology for H capsulatum, obtained for the evaluation of fever of unknown origin, revealed mycelial and yeast complement fixation titers of 1:512 with a positive M and H band on immunodiffusion.
leprae suspensions were incubated with normal serum and a hemolytic titer (CH50) was determined as a measure of complement fixation. Crude M.
Rheumatoid factor, anti-nuclear antibody, anti-cardiolipin antibody, complement fixation, and serum protein electrophoresis were all within normal limits.
Serologic testing using both a complement fixation assay and immunodiffusion assay is generally the best way to diagnosis histoplasmosis.
A complement fixation assay may not show positive results until 2-6 weeks after onset of acute illness, and an immunodiffusion assay often lags further behind.
They realized that the simplicity of EIA/ELISA compared very favorably with the cumbersome technology that was used in the field at that time (immunofluorescence, hemagglutination inhibition, and complement fixation) and quickly developed a wide range of tests for various microorganisms.
Documented methods of VZV antibody detection include complement fixation, IFA, fluorescent antibody to membrane antigen (FAMA), neutralization, indirect hemagglutination, immune adherence hemagglutination, radioimmunoassay, latex agglutination, and enzyme-linked immunosorbent assay (CDC 1996).

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