complementation group


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complementation group

[‚käm·plə·mən′tā·shən ‚grüp]
(genetics)
Different mutations in the same cistron or gene.
References in periodicals archive ?
Association of complementation group and mutation type with clinical outcome in Fanconi anaemia.
2001) The peroxin Pex6p gene is impaired in peroxisome biogenesis disorders of complementation group 6.
61 Abbreviations: ATM, ataxia telangiectasia-mutated; FANCC, Fanconi anemia complementation group C; UBC13, ubiquitin-conjugating enzyme 13; XPG, Xeroderma pigmentosum complementation group G; XRCC3, X-ray repair complementing defective repair in Chinese hamster cells 3.
Additionally, the different lethal complementation groups also show restricted and often localized distributions among European Mus musculus domesticus (Klein et al.
KEY WORDS: Xeroderma pigmentosum complementation group F, Single Nucleotide Polymorphism, Gastric cancer, H.
More than 15 ns-cSNPs were detected in five genes: insulin-like growth factor receptor 2 (IGF2R) with 21 ns-cSNPs, REV3-like, catalytic subunit of DNA polymerase zeta (REV3L) with 21 ns-cSNPs, protein kinase, DNA-activated, catalytic polypeptide (PRKDC) with 20 ns-cSNPs, exonuclease 1 (EXO1) with 17 ns-cSNPs, and the excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6) with 16 ns-cSNPs.
Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer.
1997) had shown that MMC-induced apoptosis in FA complementation group C (FA-C) cells occurred under normoxic conditions (associated with redox-cycling mechanisms), whereas MMC was ineffective in causing apoptosis under hypoxic conditions (with prevailing cross-link formation).
Early assay results indicate that certain candidate genes have senescence inducing activity in specific complementation group cell lines.
Loss-of-function mutations in the genes that underlie each of the FA complementation groups have been found directly or indirectly to play a role in disrupting the DNA repair pathway of cells.