condensin complex
condensin complex
[kən′den·sən ¦käm‚pleks] (cell and molecular biology)
One of the protein complexes that drive the coiling of interphase chromosomes, leading to their condensation prior to mitosis.
References in periodicals archive
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SMC1/3 form the core of the cohesin complex which mediates sister chromatid cohesion; SMC2/4 are present in the condensin complex that acts in chromosome assembly and segregation.
Furthermore, since the Nesprin-2 condensin interaction also takes place during other phases of the cell cycle and since condensins have additional functions in interphase, the Nesprin-2 condensin complex could also affect these processes.
Carroll et al., "Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis," Genes & Development, vol.
As the chromosomes condense, REC8 is cleaved on the chromosome arms and the cohesin complex is replaced by the condensin complex. The crossover point remains to ensure proper alignment, tension, and segregation of the homologous chromosomes.
I plan to use a multidisciplinary approach, combining acute protein inactivation, 4D-live cell imaging and biophysical/mathematical approaches to evaluate role of condensin complexes, one of the most abundant non-histone chromosomal proteins, in the process of chromosome assembly.
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