Immunosuppression as well as neutrophil depletion with either anti-Gr-1 or anti-Ly6G significantly reduced the number of conducting airway wall neutrophils in noninfected mice compared to their respective control-treated animals (Figure 4(d)).
[Gr-1.sup.+] and[Ly6G.sup.+] Cells in the Conducting Airway Mucosa.
Because the amount of site-specific paraffin sections was limited in these fetal lungs, we quantified only the abundance of mucosubstance in the airway epithelium of proximal (intrapulmonary generations 1-3) conducting airways, determined using stereologic assessment of lung structure (Hsia et al.
Our data indicate that exposure to environmentally relevant levels of BPA during fetal lung development can alter expression of secretory genes (Muc5B, CCSP) and proteins (MUC5B, CCSP) in the conducting airways. Further, we found that this increase was most pronounced in the proximal conducting airways, bronchi.
In this study, eNO values were assessed using multiple models and demonstrated differences in exhaled alveolar NO ([C.sub.A] NO) and conducting airway NO ([J'.sub.awNO]) between groups, depending on the type of pulmonary pathology present.
In SSc-PAH patients, increased conducting airway NO ([J'.sub.awNO]) correlated with a reduced DLCO.
In the high-dose miners, the interstitial compartments with the greatest amount of particulate material were the interlobular, intersegmental, and perivascular connective tissue; scars; the alveolar and alveolar duct septa; the pleura; bronchovascular interstitium of conducting airways
; and the interstitium of respiratory bronchioles.
Repeated episodes of exposure to ozone alters postnatal development of distal conducting airways
in infant rhesus monkeys.
Smaller particles generally deposit more peripherally in the lung, such as in the alveolar space, whereas larger particles deposit more centrally, for example, in the large conducting airways
. Particles larger than 5 [micro]m tend to deposit in the mouth-throat area , thereby reducing the lung dose.
The walls of the conducting airways
are mostly composed of epithelial lining, connective tissue elements, and a smooth muscle sleeve.
Very recently, evidence for surface tension values below 15 mJ/[m.sup.2] in the intrapulmonary conducting airways
was obtained from particle deposition studies in hamsters (Geiser et al.
This region of the lung is anatomically distinct, as the respiratory bronchioles have some of the same properties of conducting airways
as well as serving a gas-exchange function (25).