Avmo et al., "Conformationally
rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer," Nucleic Acids Research, vol.
Dipole moment of conformationally
restricted chiral biphenyl dopant 1 containing methyl, carboxylate and nitro functional groups at positions2(2?), 4(4?) and 5(5?) respectively, was calculated9.61 D whereas the dihedral angle between two rings(C2-C1-C1?-C2?) was found 54.6o and by comparing it with the reported values of dipole moment of benzene substituted derivatives, this was found veryhigh .
Using recombinant DNA technology, the L1 protein is expressed in Saccharomyces cerevisiae (yeast), and the proteins self-assemble into conformationally
intact, noninfectious VLPs.
The highly interdisciplinary area includes organic and polymer synthesis, peptide design and synthesis, self-assembled macromolecules, computational studies to complement spectroscopic higher structural order determination, and interaction of conformationally
(or higher structurally) organized oligomer polymers with biological systems.
In search of a universal combinatorial approach for the mimicry of peptide structure, his laboratory has developed effective protocols for creating conformationally
biased peptide analogs and for introducing such surrogates into peptide mimic libraries in order to study various biological systems.
The facts noted here may suggest that Periphylla luciferase has a unique and unusual tertiary structure , and that the luciferases isolated by us are mixtures of two or more molecular species having conformationally
different structures (having different activities) that are not easily separable by chromatography.
Eserine, on the other hand, was the only molecule to have its nitrogens conformationally
restricted, and it had higher than expected activity.
Molecular recognition of the inhibiter ag-1343 by hiv-1 protease: Conformationally
flexible docking by evolutionary programming.
These observations, as well as similar cytogenetic observations from a variety of murid and cricetid rodents (e.g., Murer-Orlando et al., 1983; Schmid et al., 1987; reviewed by Hale et al., 1991), indicate that pseudoautosomal heterochromatin is conformationally
and compositionally distinct from autosomal heterochromatin within the same genome.
"Then we can make a molecule that has all of the features important for biological activity, but is conformationally
constrained so it can't rotate or do anything else but look like the conformation that's recognized by the receptor or enzyme," Gadek continues.
Scott, "Targeting of a conformationally
exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy," Cancer Research, vol.
BMS631707 (7) possess a characteristic conformationally
restricted azetidinone ring linked to the carboxylic acid group, which aids the drug to occupy a new hydrophobic pocket.