Positional cloning using interval-specific congenic strains narrowed this QTL to a 0.
Because the DBA/2J and C57BL/6J mice that were used to generate the interval-specific congenic strains differ significantly in the brain levels of some oxidative stress markers (Rebrin et al.
Classical congenic strains typically are derived from two inbred progenitor strains (i.
Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval Mammalian Genome 8:163-167, 1997.
models called interval-specific congenic strains
[ISCS] and advanced intercross lines [AIL]) as well as of heterogeneous populations (see Palmer and Phillips 2002).
Using this strategy, one can produce several congenic strains
that carry different or overlapping parts of the original QTL.