congenic strain


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congenic strain

[kən¦jen·ik ′strān]
(genetics)
An animal line that differs from its inbred partner strain by only a short chromosomal segment that includes the differential locus (the locus to be studied).
References in periodicals archive ?
Positional cloning using interval-specific congenic strains narrowed this QTL to a 0.
Because the DBA/2J and C57BL/6J mice that were used to generate the interval-specific congenic strains differ significantly in the brain levels of some oxidative stress markers (Rebrin et al.
Classical congenic strains typically are derived from two inbred progenitor strains (i.
Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval Mammalian Genome 8:163-167, 1997.
models called interval-specific congenic strains [ISCS] and advanced intercross lines [AIL]) as well as of heterogeneous populations (see Palmer and Phillips 2002).
Using this strategy, one can produce several congenic strains that carry different or overlapping parts of the original QTL.