In life threatening haemorrhage uterine packing will not only halt the blood loss and preserve the uterus but also gives an opportunity to reverse and correct any consumptive coagulopathy
. By using the uterine roller packing one would expect the total blood loss to be reduced and blood products are avoided.
Finally, some animal models have suggested that consumptive coagulopathy
occurs due to the activation of platelets, factor III, factor X, and amniotic fluid tissue factor leading to disseminated intravascular coagulation (DIC).
This occurs when there is consumptive coagulopathy
and bleeding into a quickly growing angiosarcoma .
Additionally, he developed anemia requiring multiple blood transfusions, thrombocytopenia, consumptive coagulopathy
(prolonged prothrombin time (PT), activated partial thromboplastin time (aPTT), and low fibrinogen), and fibrinolysis (increased D-dimer) which were consistent with disseminated intravascular coagulation (DIC).
It arises from the activation of the coagulation cascade snake toxins including thrombin-like enzymes (most commonly), prothrombin, and factor X activators, resulting in a consumptive coagulopathy
[2, 6, 7].
While intracranial hemorrhages are related to pathology of hemostatic factors as decreased platelets or a severe consumptive coagulopathy
, the mechanism underlying ischemia is still not established.
Possible clinical presentations include also Kasabach-Merritt syndrome, which consists in a consumptive coagulopathy
due to large vascular tumours .
Congestive heart failure and consumptive coagulopathy
may develop depending on the size of the hemangioma.
The most common causes of coagulation disorders in the patients with massive bleeding or massive transfusions are: coagulopathy due to loss of blood type, dilutional coagulopathy, consumptive coagulopathy
, hyperfibrinolysis, acidosis, hypothermia, anemia and electrolyte imbalance .
Increasing amounts of antivenom have particularly been administered to patients with venom-induced consumptive coagulopathy
, based on the number of doses required before coagulation normalised.
 The causes of hemorrhage could be thrombocytopenia with coagulation defects, capillary fragility, consumptive coagulopathy
, and platelet dysfunction. Generally, there is complete resolution of ocular changes in dengue fever.
Of interest was that an association was also evident in patients with BMTB, suggesting that a consumptive coagulopathy
(such as DIC) is a likely contributor to the low platelet count frequently seen in these patients.