This study suggested that in polar body formation, one peripheral aster could determine the cleavage plane and provide the components of the contractile ring. Cleavage occurred at the level of the actin cortex.
Formation and function of the polar body contractile ring in Spisula.
1998, pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring
Furthermore, using phospho-myosin II staining as a marker for contractile-competent myosin II in the contractile ring, activated eggs demonstrated a ring structure that was associated with the microtubule bundles (Fig.
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.
RhoGEF and Rho family GTPase-activating protein complex links the contractile ring
to cortical microtubules at the onset of cytokinesis.
Therefore, the observation that actin filaments self-organized and moved in an anti-parallel fashion in these extracts fits current models of the contractile ring
. These data support models in which the bundling of actin filaments involves a calcium-sensitive step.
Therefore the observation that actin filaments self-organized and moved in an anti-parallel fashion in these extracts fits current models of the contractile ring
. These studies provide evidence that the two activities mediated by myosin-II in these extracts are activated by Rho GTPases.
A similar sliding motion produced by bipolar myosin-II filaments is generally accepted as the mechanism by which the contractile ring
constricts the cell during cytokinesis.