corepressor


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Related to corepressor: inducer, coactivator

corepressor

[¦kō·ri‚pres·ər]
(cell and molecular biology)
A certain metabolite which, through combination with a repressor apoprotein produced by a regulator gene, can cause the binding of the protein to the operator gene region of a deoxyribonucleic acid chain.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
LCORL, ligand dependent nuclear receptor corepressor like; NCAPG, non-SMC condensin I complex subunit G; LDB2, LIM domain binding 2; PROMI, prominin 1; TAPTI, transmembrane anterior posterior transformation 1.
Telmisartan functions blocking angiotensin receptor and as agonist partial ligand of PPAR-[gamma] so that PPAR-[gamma] formed heterodimerisation with RXRs which induces inhibitor corepressor formation of TGF-[beta]1 gene expression.
In particular, characterizing the interactions of corepressors in the pathway provides valuable information about regulation of Notch signaling.
Bcor has been identified as a transcriptional corepressor and known to regulate gene expression in association with epigenetic-modifying complexes including Polycomb group (PcG) proteins, Skp-Cullin-F-box (SCF) ubiquitin ligase, and histone demethylase [34, 35].
Extensive research undertaken to improve the efficacy and/or safety of first-generation PPAR[gamma] agonists (the TZDs) has led to a greater understanding of the complexity of PPAR regulation, specifically the importance of coactivator and corepressor proteins.
Round cell tumors of soft tissue constitute a divergent group of neoplasms, largely including Ewing sarcoma, rhabdomyosarcoma, desmoplastic small round cell tumor, neuroblastoma, and recently characterized CIC (capicua transcriptional suppressor)-rearranged sarcoma and BCOR (Bcl-6 corepressor)-rearranged sarcoma.
In the absence of RA, RAR/RXR recruits transcriptional repressors such as nuclear receptor corepressor (N-CoR) and neuron-restrictive silencer factor/repressor element-1 silencing transcription factor (NRSF/REST) into their complex with histone deacetylases (HDACs), which bring about a closed chromatin structure and suppress the transcription.
These 26 genes contained fibroblast growth factor receptor 1, G protein subunit alpha q, RB transcriptional corepressor 1, ABL proto-oncogene 1, B-Raf proto-oncogene, fibroblast growth factor receptor 3, guanine nucleotide-binding protein alpha stimulating ( GNAS ), HRas proto-oncogene ( HRAS ), fms-related tyrosine kinase 3, AKT serine/threonine kinase 1, ret proto-oncogene, cadherin 1 ( CDH1 ), cyclin-dependent kinase inhibitor 2A, HER2 , enhancer of zeste 2 polycomb repressive complex 2 subunit, isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, MET proto-oncogene, mutL homolog 1 ( MLH1 ), neuroblastoma RAS viral oncogene homolog ( NRAS ), catenin beta 1, janus kinase 2, NOTCH1 , protein tyrosine phosphatase nonreceptor type 11, janus kinase 3, and MPL proto-oncogene.
CTBP2 is well known to function as a transcriptional corepressor and modulator of several essential tumorigenic processes, including growth, proliferation, and invasion, in a variety of cancer cells [25].
BCOR encodes BCL6 interacting corepressor. BCL6 is a zinc-finger transcriptional repressor and key regulator of germinal center reaction that is frequently translocated and hypermutated in DLBCL [25].