corepressor


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Related to corepressor: inducer, coactivator

corepressor

[¦kō·ri‚pres·ər]
(cell and molecular biology)
A certain metabolite which, through combination with a repressor apoprotein produced by a regulator gene, can cause the binding of the protein to the operator gene region of a deoxyribonucleic acid chain.
References in periodicals archive ?
AtERF7, an APETALA2/EREBP-type transcription factor that plays an important role in abscisic acid response, interacts with the Arabidopsis homologue of the global corepressor of transcription AtSin3, which in turn may interact with HDA19 and enhance the transcriptional repression activity (Song et al.
MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2.
The researchers say their results are a milestone in our understanding of certain fundamental mechanisms of living organisms, in particular the little-studied role of corepressors.
Alternatively, the binding of a SERM to an estrogen receptor may result in a different conformational change, making the binding of the coactivators more difficult or even causing the binding of a corepressor.
Another protein, called Lxc (formerly called Bof and located within the ImmT region of P1), enhances binding of C1 repressor to certain operator sites along the DNA and is sometimes referred to as a corepressor.
Histone deacetylases (HDACs) 1 and 2 are highly conserved enzymes that help regulate chromatin structure as the core catalytic components of corepressor complexes (Brunmeir et al.
Transcription corepressor CtBP is an NAD+-regulated dehydrogenase.
Their research revealed a new and previously unsuspected role for nuclear receptor corepressor (NCoR), a transcriptional coregulatory protein found in a wide variety of cells.
Unlike coactivators, AR corepressor proteins can form complexes with AR and inhibit the transcription of AR-regulated genes.
A Newly Identified Role of Nuclear Receptor Corepressor, SMRT (Silencing Mediator of Retinoid and Thyroid) in Improving Hyperglycemia and Insulin Sensitivity in Obese and Diabetic Mice (Late-Breaking Poster) Authors: S.
Studies have identified about 30 different estrogen-receptor-enhancing, or coactivator, proteins, and a few receptor-suppressing, or corepressor, proteins.