One study demonstrated thinner bilateral precentral cortices and reduced GM volume, while changes in FA and MD in the corticospinal tract
were not noticeable. Some studies, however, indicated that both GM and WM had significant alterations in ALS. As stated by a previous research, the WM damage was more remarkable than the GM damage at baseline, presenting as impairment in the corticospinal tract
and corpus callosum and GM loss in left motor cortices and temporal areas; however, alterations in the GM turned out to be more prominent during follow-up. This is consistent with our results, which suggest that ALS might feature WM involvement at the initial stage and develop extensive cortical degeneration gradually.
Ephrin-B3 is the midline barrier that prevents corticospinal tract
axons from recrossing, allowing for unilateral motor control.
(5) In patients with iNPH, in addition to altered CSF flow, enlarged ventricles compress the corticospinal tracts
in the lateral ventricles, (6) which is theorized to induce PBA symptoms.
The aim of this proposal is to develop a novel strategy to repair the corticospinal tract
(CST) after cervical spinal injury in the mouse.
(b) A fiber tracking image reconstructed corticospinal tract
in both hemispheres.
Schlaug, "Detection and predictive value of fractional anisotropy changes of the corticospinal tract
in the acute phase of a stroke," Stroke, vol.
Lundell et al., "Impaired transmission in the corticospinal tract
and gait disability in spinal cord injured persons," Journal of Neurophysiology, vol.
The etiology is unclear but hyperexcitability of the facial neurons secondary to demyelination of corticospinal tract
fibers is proposed .
Li, "Functional repair of the corticospinal tract
by delayed transplantation of olfactory ensheathing cells in adult rats," Journal of Neuroscience, vol.
It has been reported that before complete spinal cord crush, conditional deletion of the PTEN gene promotes compensatory sprouting of uninjured corticospinal axons; it is also supposed that the regeneration of a large number of injured corticospinal tract
(CST) axons crosses the injury site; besides, synapses in spinal segments distal to the injury were reformed by these regenerating CST axons, even though nothing was done to the glial scar formation.
* white matter tracts: corticospinal tract
, reticulospinal tracts and afferent tracts, e.g.
The corticospinal tract
(CST) is a band of nerve fibers that travels from the brain, through the brain stem and into the spinal cord.