The median age at the time of surgery was 49 years for patients with corticotroph adenomas, similar to the other analyzed adenoma subtypes.
Corticotroph adenomas showed the lowest mean ID score (1.79, 95% CI 1.34-2.25) which was significantly lower compared to nonfunctioning pituitary adenomas (p = 0.001, see Table 3 and Figure 3(a)).
To investigate that targeting USP8 with its specific inhibitor might exhibit an anticancer effect in the corticotroph adenomas, we first examined the effect of USP8 inhibitor on downstream protein levels including EGFR, ERBB2, and Met.
Two recent studies demonstrated that the USP8 gene is frequently mutated in corticotroph adenomas.[sup], ACTH adenomas harboring USP8 mutant had higher EGFR levels, expressed more POMC mRNAs, and had higher ACTH production than those with wild-type USP8.
Clinicopathologic correlations of silent corticotroph adenomas of the pituitary: report of four cases and literature review.
Silent corticotroph adenomas: further clinical and pathological observations.
Feelders et al., "Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas
, " The Journal of Clinical Endocrinology and Metabolism, vol.