cowpox


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Related to cowpox: cowpox vaccine

cowpox,

infectious disease of cows caused by a virus related to the virus of smallpox. Also called variola, it is characterized by pustular lesions on the teats and udder. Cowpox is transmitted by contact, inducing a mild infection of the hands in persons who milk infected cows. The fact that such persons had immunity to smallpox led Edward JennerJenner, Edward,
1749–1823, English physician; pupil of John Hunter. His invaluable experiments beginning in 1796 with the vaccination of eight-year-old James Phipps proved that cowpox provided immunity against smallpox.
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 to attempt vaccinationvaccination,
means of producing immunity against pathogens, such as viruses and bacteria, by the introduction of live, killed, or altered antigens that stimulate the body to produce antibodies against more dangerous forms.
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 with this virus, instead of using the dangerous method of vaccinating with material from the sores of smallpox. Jenner's method was successful and is the basis of the modern vaccination against smallpox. Horses and sheep may contract a similar disease.

cowpox

[′kau̇‚päks]
(veterinary medicine)

cowpox

a contagious viral disease of cows characterized by vesicles on the skin, esp on the teats and udder. Inoculation of humans with this virus provides temporary immunity to smallpox. It can be transmitted to other species, esp cats
References in periodicals archive ?
Now here's the good bit, because after James has had the cowpox, I'm going to deliberately try to infect him with smallpox, yes, I know it's a known killer, but trust me, I know what I'm doing.
1] Nonstandard abbreviations: VAR, variola major virus; MPV, monkeypox virus; CML, camelpox virus; VAC, vaccinia virus; CPV, cowpox virus; FRET, fluorescence resonance energy transfer; HA, hemagglufinin gene; ENIVD, European Network for the Diagnosis of Imported Viral Diseases; and geq, genome equivalents.
Through a series of tests slated for next year, the CDC hopes to develop a genetic portrait of the virus used in the vaccine--likely cowpox.
Prior to admission, all children were given a cowpox vaccination to prevent smallpox, and some orphanages employed a chirurgeon who provided the necessary medical care.
It had been three-quarters of a century since Jenner had successfully prevented smallpox by inoculating people with cowpox, a much milder disease that conferred immunity to the more serious one (see 1796).
Malcolm Skolnick, CytoGenix President and CEO commented, "We believe that there is an opportunity to develop a smallpox DNA vaccine that will be safer and more effective than the live cowpox vaccine currently available.
We first validated the specificity in silico during the design process, revealing the highest identity of 88% to cowpox virus Kostroma (GenBank accession no.
Jenner inserted pus taken from a cowpox pustule into an incision on the boy's arm, testing his theory that milkmaids who suffered the mild disease of cowpox never contracted smallpox.
Edward Jenner of England discovered that inoculation with cowpox, a milder version of smallpox, was less risky and just as effective.
Modern public health began 210 years ago, in 1796, when Edward Jenner, using material from a cowpox lesion on the hand of Sarah Nelmes, vaccinated James Phipps.
The new vaccine, called MVA85A by researchers, consists of weakened cowpox virus that has been genetically engineered to make a protein normally found on the surface of M.
When Edward Jenner started it all in 1796 he injected a child with the cowpox virus as a means of protecting him or her against smallpox.